Document Detail

Effects of antihypertensive drugs on intracranial hypertension.
MedLine Citation:
PMID:  1950224     Owner:  NLM     Status:  MEDLINE    
The effects of antihypertensive drugs, such as nifedipine, chlorpromazine, reserpine and thiopental on mean arterial blood pressure (ABP), mean intracranial pressure (ICP) and cerebral perfusion pressure (CPP) were studied in 43 patients with systemic hypertension and intracranial hypertension due to hemorrhagic cerebrovascular diseases and other causes. These drugs are commonly used in neurosurgical practice for the treatment of systemic hypertension. Nifedipine, chlorpromazine and reserpine reduced the mean ABP, raised the mean ICP and decreased the CPP. The effects of these drugs on mean ICP and CPP were more pronounced in patients with severely increased ICP (more than 40 mmHg) than in patients with moderately increased ICP (20-40 mmHg). Thiopental reduced both mean ABP and ICP, whereas the CPP was unchanged from the preadministration level. During thiopental administration, however, respiratory depression was observed, and hence, intubation and ventilation were required. We suggest that, in the treatment of systemic hypertension in patients with increased ICP, barbiturates are more desirable than agents with calcium channel or alpha-adrenergic blocking actions, despite the problem of respiratory control.
S Hirose; Y Handa; H Kobayashi; H Kawano; J Nozaki; M Hayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zentralblatt für Neurochirurgie     Volume:  52     ISSN:  0044-4251     ISO Abbreviation:  Zentralbl. Neurochir.     Publication Date:  1991  
Date Detail:
Created Date:  1991-12-03     Completed Date:  1991-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0413646     Medline TA:  Zentralbl Neurochir     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  69-75     Citation Subset:  IM    
Department of Neurosurgery, Fukui Medical School.
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MeSH Terms
Antihypertensive Agents / adverse effects*
Blood Pressure / drug effects*,  physiology
Brain Edema / physiopathology
Cerebral Hemorrhage / physiopathology
Cerebrospinal Fluid Pressure / drug effects*,  physiology
Chlorpromazine / adverse effects,  therapeutic use
Hypertension / drug therapy*,  physiopathology
Intracranial Pressure / drug effects*,  physiology
Middle Aged
Nifedipine / adverse effects,  therapeutic use
Pseudotumor Cerebri / physiopathology*
Reserpine / adverse effects,  therapeutic use
Thiopental / adverse effects,  therapeutic use
Reg. No./Substance:
0/Antihypertensive Agents; 21829-25-4/Nifedipine; 50-53-3/Chlorpromazine; 50-55-5/Reserpine; 76-75-5/Thiopental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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