Document Detail

Effects of antihypertensive agents on coronary artery disease risk factors.
MedLine Citation:
PMID:  1546637     Owner:  NLM     Status:  MEDLINE    
The adverse effects of certain antihypertensive medications, most notably diuretics and beta blockers, on serum lipids, glucose, and potassium may explain why control of hypertension has not been accompanied by declines in coronary artery disease. Evidence indicates that angiotensin-converting enzyme (ACE) inhibitors, including quinapril, the newest member of this class of drugs, have no deleterious effects on these coronary risk factors. In addition to differences in chemical structure, the unique activity of quinapril at the local tissue level might to some degree explain its comparatively favorable clinical profile. Consequently, ACE inhibiting agents may be better choices for the management of patients with mild-to-moderately elevated blood pressure. However, controlled clinical trials with these drugs are needed to determine their impact on events related to coronary artery disease.
J A Schoenberger
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  69     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-04-15     Completed Date:  1992-04-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33C-39C     Citation Subset:  AIM; IM    
Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Antihypertensive Agents / adverse effects*
Blood Glucose / drug effects*
Coronary Disease / blood*,  chemically induced
Lipoproteins / drug effects*
Potassium / blood*
Risk Factors
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Blood Glucose; 0/Lipoproteins; 7440-09-7/Potassium
Comment In:
Am J Cardiol. 1993 Feb 15;71(5):493-4   [PMID:  8430656 ]

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