Document Detail


Effects of antihypertensive agents on coronary artery disease risk factors.
MedLine Citation:
PMID:  1546637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The adverse effects of certain antihypertensive medications, most notably diuretics and beta blockers, on serum lipids, glucose, and potassium may explain why control of hypertension has not been accompanied by declines in coronary artery disease. Evidence indicates that angiotensin-converting enzyme (ACE) inhibitors, including quinapril, the newest member of this class of drugs, have no deleterious effects on these coronary risk factors. In addition to differences in chemical structure, the unique activity of quinapril at the local tissue level might to some degree explain its comparatively favorable clinical profile. Consequently, ACE inhibiting agents may be better choices for the management of patients with mild-to-moderately elevated blood pressure. However, controlled clinical trials with these drugs are needed to determine their impact on events related to coronary artery disease.
Authors:
J A Schoenberger
Related Documents :
7473527 - Effects of ace inhibition on the heart.
22705607 - Incidence of ventricular arrhythmia and associated patient outcomes in hospitalized acu...
22392457 - Emerging antiplatelet therapy for coronary artery disease and acute coronary syndrome.
17948087 - A synopsis of research in cardiac apoptosis and its application to congestive heart fai...
2353657 - Measurement of intracardiac dimensions and structures in normal young adult subjects by...
15801057 - Diagnosis of coronary artery disease with dobutamine-stress mri.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  69     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-04-15     Completed Date:  1992-04-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33C-39C     Citation Subset:  AIM; IM    
Affiliation:
Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Antihypertensive Agents / adverse effects*
Blood Glucose / drug effects*
Coronary Disease / blood*,  chemically induced
Humans
Lipoproteins / drug effects*
Potassium / blood*
Risk Factors
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Blood Glucose; 0/Lipoproteins; 7440-09-7/Potassium
Comments/Corrections
Comment In:
Am J Cardiol. 1993 Feb 15;71(5):493-4   [PMID:  8430656 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Angiotensin-converting enzyme in cardiovascular and adrenal tissues and implications for successful ...
Next Document:  Effects of inhibitors of angiotensin-converting enzyme on regional hemodynamics.