Document Detail

Effects of antidepressants maprotiline and fluxilan on sympatho-adrenomedullary system in stressed rats.
MedLine Citation:
PMID:  19083273     Owner:  NLM     Status:  MEDLINE    
Influence of previous stress exposure on the effects of serotonergic and noradrenergic antidepressants on subsequent newly induced stress is still far from being completely understood. The aim of the present study was to investigate changes in the activity of the sympatho-adrenomedullary system in unstressed and chronic unpredictable mild stressed (CUMS) rats treated with either maprotiline or fluxilan, both under basal conditions and subsequent immobilization stress. Maprotiline and fluxilan elevated plasma norepinephrine in unstressed control and CUMS rats. Immobilization increased norepinephrine less in unstressed maprotiline- or fluxilan controls than in vehicle group. Subsequent immobilization elevated norepinephrine in CUMS rats the differences between the groups being insignificant. Maprotiline didn't affect epinephrine in unstressed and CUMS rats and fluxilan increased it. Subsequent immobilization elevated epinephrine in unstressed maprotiline controls less than in vehicle animals. Epinephrine increase was similar in maprotiline CUMS and vehicle CUMS rats. Immobilization of fluxilan unstressed and CUMS rats significantly increased epinephrine but without differences compared to vehicle group. Novel stressor activated sympatho-adrenomedullary system of CUMS rats upon antidepressants.
Natasa Spasojevic; Ljubica Gavrilovic; Ivan Kovacevic; Sladjana Dronjak
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-10
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  145     ISSN:  1872-7484     ISO Abbreviation:  Auton Neurosci     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  104-7     Citation Subset:  IM    
Institute of Nuclear Sciences Vinca, Laboratory of Molecular Biology and Endocrinology, 11000 Belgrade, Serbia.
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MeSH Terms
Adrenal Medulla / drug effects*,  metabolism
Antidepressive Agents / pharmacology*,  therapeutic use
Maprotiline / pharmacology*,  therapeutic use
Rats, Wistar
Serotonin Uptake Inhibitors / pharmacology*,  therapeutic use
Stress, Psychological / blood,  drug therapy*,  psychology
Sympathetic Nervous System / drug effects*,  metabolism
Reg. No./Substance:
0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors; 10262-69-8/Maprotiline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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