| Effects of antidepressant treatment following myocardial infarction. | |
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MedLine Citation:
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PMID: 17541103 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Depression following myocardial infarction is associated with poor cardiac prognosis. It is unclear whether antidepressant treatment improves long-term depression status and cardiac prognosis. AIMS: To evaluate the effects of antidepressant treatment compared with usual care in an effectiveness study. METHOD: In a multicentre randomised controlled trial, 2177 myocardial infarction patients were evaluated for ICD-10 depression and randomised to intervention (n=209) or care as usual (n=122). Both arms were evaluated at 18 months post-myocardial infarction for long-term depression status and new cardiac events. RESULTS: No differences were observed between intervention and control groups in mean scores on the Beck Depression Inventory (11.0, s.d.=7.5 v.10.2, s.d.=5.1, P=0.45) or presence of ICD-10 depression (30.5 v. 32.1%, P=0.68). The cardiac event rate was 14% among the intervention group and 13% among controls (OR=1.07, 95% CI 0.57-2.00). CONCLUSIONS: Antidepressant treatment did not alter long-term depression post-myocardial infarction status or improve cardiac prognosis. |
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Authors:
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Joost P van Melle; Peter de Jonge; Adriaan Honig; Aart H Schene; Astrid M G Kuyper; Harry J G M Crijns; Annique Schins; Dorien Tulner; Maarten P van den Berg; Johan Ormel; |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of psychiatry : the journal of mental science Volume: 190 ISSN: 0007-1250 ISO Abbreviation: Br J Psychiatry Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-06-01 Completed Date: 2008-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0342367 Medline TA: Br J Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 460-6 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University Medical Center Groningen, P.O. Box 30.001, 9700 RB, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antidepressive Agents / therapeutic use* Depressive Disorder / drug therapy*, etiology Female Follow-Up Studies Health Status Humans Male Middle Aged Myocardial Infarction / psychology* Prognosis Psychiatric Status Rating Scales / statistics & numerical data* Quality of Life Risk Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents |
| Comments/Corrections | |
Comment In:
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Br J Psychiatry. 2007 Nov;191:455-6; author reply 456-7
[PMID:
17978329
]
Br J Psychiatry. 2007 Nov;191:456; author reply 456-7 [PMID: 17978332 ] Br J Psychiatry. 2007 Jun;190:467-8 [PMID: 17541104 ] Br J Psychiatry. 2007 Nov;191:455; author reply 456-7 [PMID: 17978330 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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