Document Detail

Effects of antidepressant treatment following myocardial infarction.
MedLine Citation:
PMID:  17541103     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Depression following myocardial infarction is associated with poor cardiac prognosis. It is unclear whether antidepressant treatment improves long-term depression status and cardiac prognosis. AIMS: To evaluate the effects of antidepressant treatment compared with usual care in an effectiveness study. METHOD: In a multicentre randomised controlled trial, 2177 myocardial infarction patients were evaluated for ICD-10 depression and randomised to intervention (n=209) or care as usual (n=122). Both arms were evaluated at 18 months post-myocardial infarction for long-term depression status and new cardiac events. RESULTS: No differences were observed between intervention and control groups in mean scores on the Beck Depression Inventory (11.0, s.d.=7.5 v.10.2, s.d.=5.1, P=0.45) or presence of ICD-10 depression (30.5 v. 32.1%, P=0.68). The cardiac event rate was 14% among the intervention group and 13% among controls (OR=1.07, 95% CI 0.57-2.00). CONCLUSIONS: Antidepressant treatment did not alter long-term depression post-myocardial infarction status or improve cardiac prognosis.
Joost P van Melle; Peter de Jonge; Adriaan Honig; Aart H Schene; Astrid M G Kuyper; Harry J G M Crijns; Annique Schins; Dorien Tulner; Maarten P van den Berg; Johan Ormel;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  190     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-01     Completed Date:  2008-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  460-6     Citation Subset:  IM    
Department of Cardiology, University Medical Center Groningen, P.O. Box 30.001, 9700 RB, The Netherlands.
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MeSH Terms
Antidepressive Agents / therapeutic use*
Depressive Disorder / drug therapy*,  etiology
Follow-Up Studies
Health Status
Middle Aged
Myocardial Infarction / psychology*
Psychiatric Status Rating Scales / statistics & numerical data*
Quality of Life
Treatment Outcome
Reg. No./Substance:
0/Antidepressive Agents
Comment In:
Br J Psychiatry. 2007 Nov;191:455-6; author reply 456-7   [PMID:  17978329 ]
Br J Psychiatry. 2007 Nov;191:456; author reply 456-7   [PMID:  17978332 ]
Br J Psychiatry. 2007 Jun;190:467-8   [PMID:  17541104 ]
Br J Psychiatry. 2007 Nov;191:455; author reply 456-7   [PMID:  17978330 ]

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