| Effects of antiarrhythmic drugs on the monophasic action potential of the canine isolated, blood-perfused ventricular septum preparation. | |
| | |
MedLine Citation:
|
PMID: 10442399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study was designed to combine the monophasic action potential (MAP) recording technique with a well-established canine isolated, blood-perfused ventricular septum preparation for examining, simultaneously, electrical and mechanical drug-induced changes. A MAP catheter was positioned onto the base of a papillary muscle for recording the local MAP, using a manual micromanipulator together with a commercially available catheter sheath to keep the optimal contact pressure against the ventricular wall. The catheter sheath was filled with saline to eliminate the background electrical noise. Tetrodotoxin, disopyramide, lidocaine, and verapamil were used to clarify the potential utility of the preparation. Tetrodotoxin and lidocaine shortened the MAP duration, while disopyramide prolonged it. Verapamil slightly shortened the MAP duration but not significantly. Each drug showed negative inotropic and coronary vasodilator effects. Sodium channel blockers slowed intraventricular conduction and decreased the maximum upstroke velocity of MAP, while verapamil showed no effects. These results suggest that utilization of the blood-perfused ventricular septum preparation together with MAP recording will become a valuable model for evaluating drugs with multiple sites of action on cardiac muscles. |
| | |
Authors:
|
A Hagihara; A Sugiyama; K Hashimoto |
Related Documents
:
|
21150389 - Morphine-sensitive paroxysmal sympathetic storm in pontine intracerebral hemorrhage. 2576779 - Endothelium attenuates contractile responses of goat saphenous arteries to adrenergic n... 8067419 - Ratiometric methodology for nad(p)h measurement in the perfused rat heart using surface... 15141879 - Comparison of abomasal luminal gas pressure and volume and perfusion of the abomasum in... 11194059 - A cardiopulmonary bypass perfusion technique for the surgical repair of aortic type i d... 4084719 - Pressure changes in the dilated upper urinary tract on perfusion at varying flow rates. 972009 - Comparison of rapid versus slow decompression of the distended urinary bladder. 11696109 - High-resolution analysis of the duodenal interdigestive phase iii in humans. 6647199 - Emergency treatment of hypertensive crisis with sublingual nifedipine. |
Publication Detail:
|
Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Heart and vessels Volume: 13 ISSN: 0910-8327 ISO Abbreviation: Heart Vessels Publication Date: 1998 |
Date Detail:
|
Created Date: 1999-09-08 Completed Date: 1999-09-08 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 181-8 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Yamanashi Medical University, Nakakoma-gun, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Action Potentials
/
drug effects* Animals Anti-Arrhythmia Agents / pharmacology* Disopyramide / pharmacology Dogs Heart Septum / drug effects*, physiology Lidocaine / pharmacology Male Tetrodotoxin / pharmacology Verapamil / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Arrhythmia Agents; 137-58-6/Lidocaine; 3737-09-5/Disopyramide; 4368-28-9/Tetrodotoxin; 52-53-9/Verapamil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mechanical properties of the fetal ductus venosus and umbilical vein.
Next Document: Increased release of the soluble form of the adhesion molecules L-selectin and ICAM-1 but not E-sele...