| Effects of the antiandrogens, vinclozolin and cyproterone acetate on gonadal development in the Japanese medaka (Oryzias latipes). | |
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MedLine Citation:
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PMID: 12758004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was focused on determining the effects of exposure to antiandrogens on the gonadal development of Japanese medaka (Oryzias latipes). Test compounds included the fungicide, vinclozolin and the clinical antiandrogen, cyproterone acetate. Newly hatched medaka were exposed to aqueous solutions of vinclozolin (2500 microg/l) and the vinclozolin fungicide formulation, Ronilan (1000 and 5000 microg/l) and cyproterone acetate (1 and 10 microg/l), for 3 months. Histological evaluation of the gonadal tissues of exposed fish indicated that the 5000 microg/l concentration of the vinclozolin formulation (Ronilan) induced a low incidence of intersex (i.e. testis-ova) and the 2500 microg/l concentration of vinclozolin-affected spermatogenesis in males. Also, the vinclozolin treatments induced moderate ovarian atresia. Cyproterone acetate also induced a low incidence of testis-ova, but in contrast to the vinclozolin treatment the amount of ovarian tissue in the testis-ova was equal to or greater than the amount of testicular tissue. In the cyproterone acetate treatments, both oogenesis and spermatogenesis were moderately inhibited at all test concentrations. The results of this study indicate that antiandrogens have the potential to alter testicular development and gametogenesis in fish. However, research is needed to determine the mechanisms by which antiandrogens affect fish. |
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Authors:
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Yiannis Kiparissis; Tracy L Metcalfe; Gordon C Balch; Chris D Metcalfe |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Aquatic toxicology (Amsterdam, Netherlands) Volume: 63 ISSN: 0166-445X ISO Abbreviation: Aquat. Toxicol. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-21 Completed Date: 2003-08-20 Revised Date: 2010-12-01 |
Medline Journal Info:
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Nlm Unique ID: 8500246 Medline TA: Aquat Toxicol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 391-403 Citation Subset: IM |
Affiliation:
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Environmental and Resource Studies, Trent University, Peterborough, Ont., Canada K9J 7B8. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Androgen Antagonists / toxicity Animals Cyproterone / toxicity Female Fungicides, Industrial / toxicity* Gametogenesis / drug effects Hermaphroditic Organisms* Larva / drug effects, growth & development Male Oryzias / anatomy & histology, growth & development* Ovary / anatomy & histology, drug effects, growth & development* Oxazoles / toxicity* Sex Determination Processes / chemically induced* Sex Differentiation / drug effects* Sex Ratio Testis / anatomy & histology, drug effects, growth & development* |
| Chemical | |
Reg. No./Substance:
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0/Androgen Antagonists; 0/Fungicides, Industrial; 0/Oxazoles; 2098-66-0/Cyproterone; 50471-44-8/vinclozolin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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