Document Detail


Effects of anti-nuclear factor kappa B reagents in blocking adhesion of human cancer cells to vascular endothelial cells.
MedLine Citation:
PMID:  7545088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Transcription factor nuclear factor kappa B (NF kappa B) controls gene expression of a number of genes including cell adhesion molecules such as E-selectin, intercellular adhesion molecule 1, and vascular adhesion molecule 1. These cell adhesion molecules are known to play important roles in a critical step of tumor metastasis, arrest of tumor cells onto the venous or capillary bed of the target organ. NF kappa B is activated by extracellular signals such as those elicited by proinflammatory cytokines, tumor necrosis factor and interleukin 1 (IL-1). Here we demonstrate that IL-1 beta induces nuclear translocation of NF kappa B in human umbilical vein endothelial cells, followed by induction of cell surface expression of E-selectin, intercellular adhesion molecule-1, and vascular adhesion molecule 1, and subsequently augments adhesion of those cancer cells expressing sialyl Lewis X antigen, a ligand to E-selectin. We have also demonstrated that the adhesion of tumor cells to IL-1 beta-treated human umbilical vein endothelial cells can be inhibited by anti-NF kappa B reagents such as N-acetyl L-cysteine, aspirin, or pentoxifylline. These observations indicate the involvement of NF kappa B in cancer metastasis and the feasibility of using anti-NF kappa B reagents in preventing metastasis.
Authors:
K Tozawa; S Sakurada; K Kohri; T Okamoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  55     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-10-06     Completed Date:  1995-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4162-7     Citation Subset:  IM    
Affiliation:
Department of Molecular Genetics, Nagoya City University Medical School, Japan.
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Cell Adhesion
Cell Adhesion Molecules / biosynthesis
Cells, Cultured
Endothelium, Vascular / cytology*,  metabolism
Humans
Intercellular Adhesion Molecule-1 / biosynthesis
Interleukin-1 / pharmacology
Molecular Sequence Data
NF-kappa B / antagonists & inhibitors,  physiology*
Neoplasm Metastasis*
Reactive Oxygen Species
Vascular Cell Adhesion Molecule-1
Chemical
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Interleukin-1; 0/NF-kappa B; 0/Reactive Oxygen Species; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1

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