Document Detail

Effects of anti-nuclear factor kappa B reagents in blocking adhesion of human cancer cells to vascular endothelial cells.
MedLine Citation:
PMID:  7545088     Owner:  NLM     Status:  MEDLINE    
Transcription factor nuclear factor kappa B (NF kappa B) controls gene expression of a number of genes including cell adhesion molecules such as E-selectin, intercellular adhesion molecule 1, and vascular adhesion molecule 1. These cell adhesion molecules are known to play important roles in a critical step of tumor metastasis, arrest of tumor cells onto the venous or capillary bed of the target organ. NF kappa B is activated by extracellular signals such as those elicited by proinflammatory cytokines, tumor necrosis factor and interleukin 1 (IL-1). Here we demonstrate that IL-1 beta induces nuclear translocation of NF kappa B in human umbilical vein endothelial cells, followed by induction of cell surface expression of E-selectin, intercellular adhesion molecule-1, and vascular adhesion molecule 1, and subsequently augments adhesion of those cancer cells expressing sialyl Lewis X antigen, a ligand to E-selectin. We have also demonstrated that the adhesion of tumor cells to IL-1 beta-treated human umbilical vein endothelial cells can be inhibited by anti-NF kappa B reagents such as N-acetyl L-cysteine, aspirin, or pentoxifylline. These observations indicate the involvement of NF kappa B in cancer metastasis and the feasibility of using anti-NF kappa B reagents in preventing metastasis.
K Tozawa; S Sakurada; K Kohri; T Okamoto
Related Documents :
15610818 - Endothelial cell activation in the presence of african trypanosomes.
16636308 - Effect of apple extracts on nf-kappab activation in human umbilical vein endothelial ce...
15653568 - Nod1-mediated endothelial cell activation by chlamydophila pneumoniae.
23782578 - Actin stress fibre subtypes in mesenchymal-migrating cells.
8968618 - Molecular dynamics of the transition from l-selectin- to beta 2-integrin-dependent neut...
21168388 - Hypoxia differentially regulates vegfr1 and vegfr2 levels and alters intracellular sign...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  55     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-10-06     Completed Date:  1995-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4162-7     Citation Subset:  IM    
Department of Molecular Genetics, Nagoya City University Medical School, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Base Sequence
Cell Adhesion
Cell Adhesion Molecules / biosynthesis
Cells, Cultured
Endothelium, Vascular / cytology*,  metabolism
Intercellular Adhesion Molecule-1 / biosynthesis
Interleukin-1 / pharmacology
Molecular Sequence Data
NF-kappa B / antagonists & inhibitors,  physiology*
Neoplasm Metastasis*
Reactive Oxygen Species
Vascular Cell Adhesion Molecule-1
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Interleukin-1; 0/NF-kappa B; 0/Reactive Oxygen Species; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  CD30 ligand signal transduction involves activation of a tyrosine kinase and of mitogen-activated pr...
Next Document:  Alterations of cell surface carbohydrates and inhibition of metastatic property of murine melanomas ...