| Effects of the anti-interleukin-6 receptor antibody, tocilizumab, on serum lipid levels in patients with rheumatoid arthritis. | |
| | |
MedLine Citation:
|
PMID: 20024554 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
We investigated the effects of anti-IL-6 receptor antibody, tocilizumab (TCZ), on lipid metabolism. Nineteen patients with rheumatoid arthritis (RA), entered in clinical case-control study of SAMURAI trial at Sasebo Chuo Hospital, were examined. Nine patients received TCZ monotherapy at 8 mg/kg intravenously every 4 weeks (TCZ group) and 10 patients received conventional DMARDs (control group). Serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), apolipoprotein (Apo) A-1, Apo A-2 and Apo B as well as disease activity score (DAS), C-reactive protein and serum amyloid A protein were examined at baseline and after 3 months of the treatment. IL-6 inversely was correlated with LDL, Apo A-1 and Apo A-2, and also tended to correlate with Apo B. In TCZ group, serum levels of TC, HDL, LDL, Apo A-1 and Apo A-2 were significantly increased after 3 months treatment with TCZ. There was no significant change in Apo B, the atherogenic index, and TC/HDL by the TCZ treatment. Changes in the DAS28-ESR negatively correlated with those in TC. In one patient, whose serum level of TCZ was not detected after 3 months of the treatment, the absence of the increment in serum levels of Apo A-1 and A-2 in the patient was remarkable. All of the markers did not change during 3 months in control group. These data may raise an important issue to evaluate the impact of these alternations in lipid metabolism for longer periods in RA patients treated with TCZ. |
| | |
Authors:
|
Shin-Ya Kawashiri; Atsushi Kawakami; Satoshi Yamasaki; Takahiro Imazato; Naoki Iwamoto; Keita Fujikawa; Toshiyuki Aramaki; Mami Tamai; Hideki Nakamura; Hiroaki Ida; Tomoki Origuchi; Yukitaka Ueki; Katsumi Eguchi |
Related Documents
:
|
7325424 - Evaluation of a new precipitation procedure for estimating high density lipoprotein cho... 2397594 - Distribution of hdl2 and hdl3 in a random population of healthy french males and female... 9814464 - Long-term prospective study of body composition and lipid profiles during and after gro... 12810154 - Polymorphisms in cyp-7a1, not apoe, influence the change in plasma lipids in response t... 7325424 - Evaluation of a new precipitation procedure for estimating high density lipoprotein cho... 19423514 - The association between diet and serum concentrations of igf-i, igfbp-1, igfbp-2, and i... |
Publication Detail:
|
Type: Journal Article Date: 2009-12-19 |
Journal Detail:
|
Title: Rheumatology international Volume: 31 ISSN: 1437-160X ISO Abbreviation: Rheumatol. Int. Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
|
Languages: eng Pagination: 451-6 Citation Subset: IM |
Affiliation:
|
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan, shinya22@nagasaki-u.ac.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Primary central nervous system vasculitis: clinical experiences with 21 new European cases.
Next Document: Serum chemokines in patients with rheumatoid arthritis treated with etanercept.