Document Detail


Effects of anti-inflammatory agents on hydrochloric acid-induced pulmonary injury.
MedLine Citation:
PMID:  8887066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the effects of anti-inflammatory agents on hydrochloric acid lung injury, the heart and lungs were harvested from rats, placed in a lung chamber, constant flow perfused with whole blood, and ventilated. The following experiments were conducted: observation alone; intratracheal injection of normal saline; intratracheal hydrochloric acid; and intravenous meclofenamate or indomethacin before intratracheal hydrochloric acid. Wet-to-dry lung weights were measured. Peak airway pressures increased immediately (p < .001 vs. baseline; ANOVA) in all intratracheal groups, hydrochloric acid producing even greater (p < .05) increases than saline-effects unaltered by meclofenamate or indomethacin. The increased (p < .001 vs. baseline) 2-h pulmonary artery pressures in hydrochloric acid-treated groups were unaltered by meclofenamate or indomethacin. All hydrochloric acid-treated groups demonstrated increases (p < .05) in weight that were unchanged by meclofenamate or indomethacin. These data suggest that the beneficial effects of these medications described elsewhere, using a variety of in vivo lung injury experimental models, may be attributed to their experimental design, or to contributions from organs/systems outside the pulmonary circuit.
Authors:
C L Westervelt; E U Choe; J Arya; H L Lippton; L M Flint; J J Ferrara
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of investigative surgery : the official journal of the Academy of Surgical Research     Volume:  9     ISSN:  0894-1939     ISO Abbreviation:  J Invest Surg     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1997-01-28     Completed Date:  1997-01-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809255     Medline TA:  J Invest Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  283-91     Citation Subset:  IM    
Affiliation:
Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Cardiac Output
Hydrochloric Acid / adverse effects*
Indomethacin / pharmacology*
Male
Meclofenamic Acid / pharmacology*
Perfusion
Pneumonia, Aspiration / chemically induced*
Pulmonary Wedge Pressure
Rats
Rats, Sprague-Dawley
Respiration
Respiratory Mechanics / physiology
Time Factors
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 53-86-1/Indomethacin; 644-62-2/Meclofenamic Acid; 7647-01-0/Hydrochloric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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