| Effects of anti-hypertensive drugs on esophageal body contraction. | |
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MedLine Citation:
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PMID: 20180238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To clarify the effects of anti-hypertensive drugs on esophageal contraction and determine their possible relationship with gastro-esophageal reflux disease. METHODS: Thirteen healthy male volunteers were enrolled. Esophageal body peristaltic contractions and lower esophageal sphincter (LES) pressure were measured using high resolution manometry. All subjects were randomly examined on four separate occasions following administrations of nifedipine, losartan, and atenolol, as well as without any drug administration. RESULTS: Peristaltic contractions by the esophageal body were separated into three segments by two troughs. The peak peristaltic pressures in the mid and lower segments of the esophageal body under atenolol administration were significantly higher than those without medication in a supine position. On the other hand, peristaltic pressures under nifedipine administration were lower than those observed without drug administration. Losartan did not change esophageal body peristalsis. Atenolol elevated LES pressure and slowed peristaltic wave transition, while the effects of nifedipine were the opposite. CONCLUSION: Among the anti-hypertensive drugs tested, atenolol enhanced esophageal motor activity, which was in contrast to nifedipine. |
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Authors:
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Koichi Yoshida; Kenji Furuta; Kyoichi Adachi; Shunji Ohara; Terumi Morita; Takashi Tanimura; Shuji Nakata; Masaharu Miki; Kenji Koshino; Yoshikazu Kinoshita |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 16 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-24 Completed Date: 2010-05-03 Revised Date: 2010-09-30 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 987-91 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo-shi, Shimane 693-8501, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / pharmacology* Atenolol / pharmacology Calcium Channel Blockers / pharmacology Esophagus* / drug effects, physiology Gastrointestinal Motility / drug effects Humans Losartan / pharmacology Male Muscle, Smooth / drug effects* Nifedipine / pharmacology Peristalsis / drug effects* Sympatholytics / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Sympatholytics; 114798-26-4/Losartan; 21829-25-4/Nifedipine; 29122-68-7/Atenolol |
| Comments/Corrections | |
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