Document Detail


Effects of anti-convulsants on fatty acid metabolism in human serum.
MedLine Citation:
PMID:  3705068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of diphenylhydantoin and phenobarbital on lipids metabolism were studied by quantification of lipids in human serum with GC-MS. The ratios of palmitic acid to stearic, oleic and linoleic acids decreased in patients on diphenylhydantoin therapy. Increases of free palmitic, stearic and oleic acids concentrations as well as higher cholesterol ester levels were observed in patients receiving either diphenylhydantoin or phenobarbital. With respect to fatty acids composition of cholesterol esters and phosphatidyl-choline, higher concentrations of palmitic, oleic and linoleic acids were observed in patients on diphenylhydantoin and phenobarbital therapy. Although the concentration of palmitic acid in serum phosphatidylcholine remained the same for all groups, a marked decrease in stearic, oleic and linoleic acids concentrations in serum phosphatidylcholine was observed in diphenylhydantoin treated group, and oleic acid in phenobarbital treated group. These results suggested the relationship to lecithin-cholesterol acyltransferase activity by these drugs.
Authors:
H Okabe; M Lehrer; A Karmen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  148     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-06-10     Completed Date:  1986-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  267-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anticonvulsants / pharmacology*
Child
Cholesterol / blood
Cholesterol Esters / blood
Fatty Acids / blood*
Gas Chromatography-Mass Spectrometry
Humans
Linoleic Acid
Linoleic Acids / blood
Oleic Acid
Oleic Acids / blood
Palmitic Acid
Palmitic Acids / blood
Phenobarbital / pharmacology
Phenytoin / pharmacology
Phosphatidylcholines / blood
Stearic Acids / blood
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Cholesterol Esters; 0/Fatty Acids; 0/Linoleic Acids; 0/Oleic Acids; 0/Palmitic Acids; 0/Phosphatidylcholines; 0/Stearic Acids; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid; 50-06-6/Phenobarbital; 57-10-3/Palmitic Acid; 57-11-4/stearic acid; 57-41-0/Phenytoin; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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