| Effects of antenatal steroid therapy on mortality and morbidity in very low birth weight infants. | |
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MedLine Citation:
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PMID: 2418190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A cohort of 678 consecutive very low birth weight infants, liveborn in one tertiary institution during a 63-month period, was studied to investigate whether antenatal steroid therapy had any beneficial or harmful effects on mortality or morbidity over the first 2 years of life. Comparing the 244 babies who received treatment with the 434 controls, 195 (79.9%) and 265 (61.1%), respectively, were discharged home (P less than 0.001). Mortality in the treated group remained substantially lower and was almost halved after adjustment for birth weight, extreme immaturity, lethal malformations, and confounding obstetric variables (P = 0.001). Fatal cases of respiratory distress syndrome were less common in the treated group (P = 0.044). Of in-hospital survivors, those in the treated group required less positive pressure respiratory support (P = 0.003) and fewer days in oxygen (P = 0.018), and the incidences of bronchopulmonary dysplasia (P = 0.003) and patent ductus arteriosus (P = 0.002) were lower. Two-year survivors who had received treatment were heavier (P = 0.016) and had larger head circumferences (P = 0.029). These beneficial associations in the treated group were not at the expense of increased rates of infection or adverse neurologic outcome. We did not detect any adverse effects of antenatal steroid therapy on any relevant aspect of mortality or morbidity in infancy under circumstances in which the chances of finding substantial differences were high. |
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Authors:
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L W Doyle; W H Kitchen; G W Ford; A L Rickards; J V Lissenden; M M Ryan |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 108 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1986 Feb |
Date Detail:
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Created Date: 1986-03-14 Completed Date: 1986-03-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 287-92 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Betamethasone
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therapeutic use* Bronchopulmonary Dysplasia / prevention & control Central Nervous System Diseases / epidemiology Child, Preschool Clinical Trials as Topic Developmental Disabilities / epidemiology Ductus Arteriosus, Patent / prevention & control Female Fetal Organ Maturity Follow-Up Studies Humans Infant Infant, Low Birth Weight* Infant, Newborn Lung / embryology Male Pregnancy Respiratory Distress Syndrome, Newborn / mortality, prevention & control* Time Factors |
| Chemical | |
Reg. No./Substance:
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378-44-9/Betamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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