Document Detail

Effects of antenatal glucocorticoids on pulmonary vascular reactivity in the ovine fetus.
MedLine Citation:
PMID:  12861164     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Although mechanisms of glucocorticoids-induced parenchymal lung maturation have been largely studied, little is known about the pulmonary vascular effects of antenatal glucocorticoids (GCs). We therefore hypothesized that antenatal GCs may alter the hemodynamic response to vasodilatory agents in the fetal lung. STUDY DESIGN: We tested the hemodynamic response to acetylcholine, increased PaO(2), and norepinephrine infusion before and after maternal GC administration in chronically prepared, late-gestation fetal lambs (135-137 days of gestational age, term = 147 days). RESULTS: We found that antenatal GCs (1). do not change the basal pulmonary vascular tone and (2). do not alter the vasodilatory response to acetylcholine and increased PaO (2) but enhanced the norepinephrine-mediated pulmonary vasodilation. CONCLUSION: Our results indicate that antenatal GCs alter the pulmonary vascular reactivity to catecholamines. We speculate that the benefits of antenatal GCs on the cardiovascular adaptation at birth may be related to potentiation of catecholamines vascular effects.
Philippe Deruelle; Veronique Houfflin-Debarge; Eric Magnenant; Sophie Jaillard; Y Riou; Francis Puech; Laurent Storme
Related Documents :
6522144 - Perinatal rat lung retinol (vitamin a) and retinyl palmitate.
9589844 - A risk-benefit assessment of natural and synthetic exogenous surfactants in the managem...
3756914 - Strain-dependent differences in the metabolism of 3-methylcholanthrene by maternal, pla...
10385594 - Lung growth response after tracheal occlusion in fetal rabbits is gestational age-depen...
22546424 - Cystically degenerated leiomyoma of the rectosigmoid managed laparoscopically at 13 wee...
23244994 - 160 conception rates following treatment of lactating holstein recipients with a gonado...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  189     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-15     Completed Date:  2003-08-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  208-15     Citation Subset:  AIM; IM    
Department of Obstetrics, Centre Hospitalier Régional Universitaire de Lille, Lille, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acetylcholine / pharmacology
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Gestational Age
Glucocorticoids / administration & dosage*
Heart Rate / drug effects
Hemodynamics / drug effects
Hydrogen-Ion Concentration
Lung / blood supply*,  embryology*
Norepinephrine / pharmacology
Oxygen / administration & dosage
Pulmonary Artery / drug effects,  embryology,  physiology
Vasodilation / drug effects
Reg. No./Substance:
0/Glucocorticoids; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Uterine contractile response to the graded infusion of oxytocin in guinea pigs near term.
Next Document:  Ultrastructural changes in omental resistance artery in women with preeclampsia.