| Effects of antenatal betamethasone on maternal and fetoplacental matrix metalloproteinases 2 and 9 activities in human singleton pregnancies. | |
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MedLine Citation:
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PMID: 16984797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A single course of antenatal betamethasone is administered to women at risk of preterm labor to advance fetal lung maturation. Matrix metalloproteinases (MMPs) are collagen-degrading enzymes that remodel extracellular matrix components during lung development. We tested the hypothesis that the effects of betamethasone on fetal lung maturation involve changes in MMP activity. METHODS: We conducted a prospective, observational pilot study of three groups of singleton pregnancies. Group 1 (n = 21) was composed of women who were antenatally treated with a single course of betamethasone and who delivered < 37 weeks of gestation, group 2 (n = 7) was composed of matched untreated women who delivered < 37 weeks of gestation, and group 3 (n = 15) was composed of untreated women who delivered > 37 weeks of gestation. Maternal blood, mixed cord blood, and placental samples were collected at the time of delivery for MMP-2 and MMP-9 activity and tissue inhibitor of metalloproteinases (TIMP)-1 and -2 levels. RESULTS: MMP-2 activity was significantly higher in the maternal, placental, and fetal compartments in group 1 compared with group 2 (p < .05). TIMP-2 levels were lower in groups 1 and 2 compared with group 3. Maternal TIMP-2 levels were higher (p < 0.003), whereas fetal TIMP-1 (p < .01) and MMP-9 to TIMP-1 ratios (p < .05) were lower when delivery was delayed more than 2 weeks following betamethasone treatment. CONCLUSION: We conclude that elevated MMP-2 activity in the maternal and fetoplacental compartments may suggest a mechanism, in part, for betamethasone-induced fetal lung maturation. |
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Authors:
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Zahra Gharraee; Kay D A Beharry; Arwin M Valencia; Steve Cho; Leonel Guajardo; Michael P Nageotte; Houchang D Modanlou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of investigative medicine : the official publication of the American Federation for Clinical Research Volume: 54 ISSN: 1081-5589 ISO Abbreviation: J. Investig. Med. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-09-20 Completed Date: 2007-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9501229 Medline TA: J Investig Med Country: Canada |
Other Details:
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Languages: eng Pagination: 245-54 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of California, Irvine, Orange, CA 92868, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Betamethasone / pharmacology* Female Fetus / drug effects*, enzymology Humans Matrix Metalloproteinase 2 / metabolism* Matrix Metalloproteinase 9 / metabolism* Placenta / drug effects*, enzymology Pregnancy / metabolism* Prospective Studies Tissue Inhibitor of Metalloproteinase-1 / blood |
| Chemical | |
Reg. No./Substance:
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0/Tissue Inhibitor of Metalloproteinase-1; 378-44-9/Betamethasone; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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