| Effects of an angiotensin inhibitor on adrenocortical response to angiotensin II, ACTH, and K. | |
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MedLine Citation:
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PMID: 174449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A competitive inhibitor of angiotensin II has been studied in nephrectomized dogs treated with dexamethasone to suppress ACTH secretion. The inhibitor, [1-sarcosine, 8-alanine]angiotensin II (P113), has been shown by previous investigators to inhibit the pressor action of angiotensin II but not the pressor effect of other pressor agents. The present experiments demonstrate that P113 inhibits the stimulation of aldosterone secretion by angiotensin II but not by ACTH or potassium infusions. Therefore, P113 appears to be a specific inhibitor of angiotensin's action on both vascular and adrenocortical tissue. In this dog preparation, P113 has a mild nondose-related agonistic action on the blood pressure and a nonsignificant action on aldosterone secretion, although in some dogs P113 appears to have a definite agonist effect. |
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Authors:
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B H Forman; A Fernandez-Cruz; Z J Kuczala; P J Mulrow |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 229 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1975 Dec |
Date Detail:
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Created Date: 1976-03-20 Completed Date: 1976-03-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1713-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex
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physiology* Adrenal Glands / physiology* Adrenocorticotropic Hormone / pharmacology* Aldosterone / secretion* Angiotensin II / analogs & derivatives*, antagonists & inhibitors*, pharmacology* Animals Blood Pressure Dogs Male Potassium / pharmacology* Receptors, Adrenergic Saralasin / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic; 11128-99-7/Angiotensin II; 34273-10-4/Saralasin; 52-39-1/Aldosterone; 7440-09-7/Potassium; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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