Document Detail

Effects of angiotensin converting enzyme inhibitor and calcium channel blocker on normoxic and hypoxic pulmonary vascular tone in unanesthetized sheep.
MedLine Citation:
PMID:  3323557     Owner:  NLM     Status:  MEDLINE    
We evaluated the effects of captopril and nifedipine on normoxic and hypoxic pulmonary vascular tone in unanesthetized sheep. Infusion of captopril (10 micrograms/kg/min) in normoxia revealed a tendency to increase the mean pulmonary arterial pressure (Ppa) and the pulmonary vascular resistance (PVR) following the systemic vasodilation. A statistically significant increase was reached by 20 minutes. Hypoxia of 10% oxygen in nitrogen produced a prominent pulmonary hypertensive response. Captopril significantly decreased the hypoxic values of Ppa and PVR from 20.3 +/- 1.3 to 17.1 +/- 1.1 mmHg (p less than 0.01) and from 4.31 +/- 0.45 to 3.49 +/- 0.45 mmHg/L/min (p less than 0.01), respectively. Infusion of nifedipine (10 micrograms/kg/min) in normoxia caused an increase in Ppa from 15.5 +/- 0.9 to 18.9 +/- 1.0 mmHg (p less than 0.01), but not in PVR. This elevation in Ppa was considered to be derived from the significant increase in the cardiac output. Nifedipine significantly decreased the hypoxic values of Ppa and PVR from 21.3 +/- 1.5 to 19.3 +/- 1.5 mmHg (p less than 0.05) and from 3.88 +/- 0.30 to 27.3 +/- 0.13 mmHg/L/min (p less than 0.01), respectively. Captopril and nifedipine produced systemic hypotensive responses during both normoxic and hypoxic ventilation. It is concluded that both captopril and nifedipine are potent pulmonary vasodilating drugs in animal subjects with a hypoxic condition and that they might be useful in the clinical vasodilator therapy of hypoxic pulmonary hypertension in man.
K Yoshimura; T Kobayashi; S Kusama; A Sakai; G Ueda
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Japanese circulation journal     Volume:  51     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-03-07     Completed Date:  1988-03-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1138-46     Citation Subset:  IM    
First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Anoxia / physiopathology*
Calcium Channel Blockers / pharmacology*
Captopril / pharmacology
Hemodynamics / drug effects
Muscle Tonus / drug effects*
Muscle, Smooth, Vascular / drug effects*
Nifedipine / pharmacology
Pulmonary Artery
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 62571-86-2/Captopril

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