Document Detail

Effects of angiotensin-converting enzyme inhibition in diabetic rats with reduced renal function.
MedLine Citation:
PMID:  1453108     Owner:  NLM     Status:  MEDLINE    
To test the effect of converting enzyme inhibition (CEI) on diabetes, with or without renal insufficiency, we studied streptozotocin-induced diabetic rats, with or without reduced renal mass, which were treated with insulin in sufficient amounts to maintain glucose values in the mild to moderately hyperglycemic range. We found that diabetes increased glomerular filtration rate (GFR) (inulin clearance, 2.3 +/- 0.5 ml/min vs 1.9 +/- 0.1 ml/min; p < 0.05) and blood pressure (137 +/- 15 mm Hg vs 116 +/- 6 mm Hg; p < 0.05) but did not increase plasma atrial natriuretic peptide (ANP) values, when compared with control rats (72 +/- 38 vs 68 +/- 24 pg/ml). CEI decreased GFR and blood pressure to control values. In rats with diabetes and concomitantly reduced renal mass, hypertension, elevated ANP values, proteinuria, and glomerulosclerosis were prominent features. CEI was associated with reduced blood pressure (172 +/- 17 mm Hg vs 138 +/- 15 mm Hg; p < 0.05), without a concomitant decrease in GFR (1.1 +/- 0.1 ml/min vs 1.1 +/- 0.1 ml/min). Further, CEI reduced the elevated ANP values (140 +/- 34 pg/ml vs 66 +/- 19 pg/ml; p < 0.05) to those of control rats. CEI reduced proteinuria by 50% and ameliorated the histopathologic changes. In separate experiments, rats with 5/6th nephrectomy and hypertension but without diabetes were also found to have elevated ANP levels that decreased to control values with CEI. The data speak for a renal protective effect of angiotensin I-converting enzyme inhibition in this model but do not support a specific role for ANP in the model of diabetes with concomitantly reduced renal mass.
H Geiger; U Bahner; W Vaaben; J Dammrich; A Heidland; F C Luft
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  120     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-01-06     Completed Date:  1993-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  861-8     Citation Subset:  AIM; IM    
Department of Medicine-Nephrology, University of Erlangen-Nünberg, Germany.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology*
Atrial Natriuretic Factor / blood,  physiology
Blood Pressure / drug effects
Body Weight / drug effects
Diabetes Mellitus, Experimental / physiopathology*
Diabetic Nephropathies / physiopathology
Glomerular Filtration Rate / drug effects
Kidney / pathology,  physiopathology*
Kidney Failure / physiopathology*
Rats, Wistar
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 85637-73-6/Atrial Natriuretic Factor
Comment In:
J Lab Clin Med. 1992 Dec;120(6):814-5   [PMID:  1453098 ]

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