| Effects of angiotensin II type 1 receptor antagonist, losartan, on ventilatory response to exercise and neurohormonal profiles in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 15040844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic heart failure (CHF) is associated with abnormal neurohormonal profiles and increased ventilatory response to exercise. This study determined if treatment with angiotensin II type 1 receptor antagonist, losartan, improves ventilatory efficiency and neurohormonal factors in patients with CHF. Symptom-limited cardiopulmonary exercise testing was performed after a 2-week placebo period (baseline) and after 16 weeks of treatment with losartan (40 +/- 4 mg/day) in 10 patients with CHF (age 57.7 +/- 3.7 years). Echocardiogram, daily physical activity (by the specific activity scale), and neurohormones were evaluated. Treatment with losartan increased left ventricular ejection fraction (baseline vs. losartan: 31 +/- 3 vs. 39 +/- 3%, p<0.01) and specific activity scale score (5.3 +/- 0.5 vs. 6.4 +/- 0.4 METS, p<0.05). Losartan decreased the ventilatory response to carbon dioxide production during exercise (VE/VCO2 slope: 34.6 +/- 2.4 vs. 32.0 +/- 2.2, p<0.05). Plasma brain natriuretic peptide concentrations were decreased after therapy (301 +/- 79 vs. 176 +/- 53 pg/ml, p<0.05). In summary, the results of this open-label, uncontrolled study suggest that chronic treatment with losartan may improve ventilatory efficiency and decrease plasma brain natriuretic peptide concentrations with the improvement of physical activity and left ventricular systolic function in patients with CHF. |
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Authors:
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Toru Kinugawa; Masahiko Kato; Kazuhide Ogino; Shuichi Osaki; Osamu Igawa; Ichiro Hisatome; Chiaki Shigemasa |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: The Japanese journal of physiology Volume: 54 ISSN: 0021-521X ISO Abbreviation: Jpn. J. Physiol. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-03-25 Completed Date: 2004-12-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985184R Medline TA: Jpn J Physiol Country: Japan |
Other Details:
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Languages: eng Pagination: 15-21 Citation Subset: IM |
Affiliation:
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Department of Cariovascular Medicine, Tottori University Faculty of Medicine, Yonago, 683-8504 Japan. kinugawa@grape.med.tottori-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II Type 1 Receptor Blockers
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therapeutic use Chronic Disease Female Heart Failure / blood*, complications, diagnosis, drug therapy* Humans Hyperventilation / blood, diagnosis, drug therapy*, etiology Losartan / therapeutic use* Male Middle Aged Neurotransmitter Agents / blood* Pulmonary Ventilation / drug effects* Treatment Outcome Ventricular Dysfunction, Left / blood, diagnosis, drug therapy*, etiology |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Neurotransmitter Agents; 114798-26-4/Losartan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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