Document Detail

Effects of angiotensin II on blood flow in rat submandibular gland.
MedLine Citation:
PMID:  1950599     Owner:  NLM     Status:  MEDLINE    
The effect of angiotensin II (Ang II) was studied on blood flow in the submandibular gland and tongue in male rats. Blood flow changes were determined with laser Doppler flowmetry and Ang II was infused into the common carotid artery before and after i.v. doses (18 nmol kg-1) of the angiotensin II antagonist saralasin. Angiotensin II (10-60 pmol min-1) dose-dependently increased blood pressure and tongue blood flow, whereas glandular blood flow decreased at all of the doses used. After saralasin administration the angiotensin II effects on blood pressure, tongue and glandular blood flow were significantly diminished (glandular blood flow reduction was diminished from 29%-3%, P less than 0.005, n = 9). However, the responsiveness of these 3 parameters to local infusions with noradrenaline (0.75-3.0 pmol min-1) was unaffected by saralasin. The dose of saralasin used in the present study did not affect any of the parameters on it's own. Our results show that vascular receptors sensitive to angiotensin II operate in the submandibular gland but not in the tongue.
A Fazekas; L Olgart; B Gazelius; N Kerezoudis; L Edwall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  142     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-03     Completed Date:  1991-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  503-7     Citation Subset:  IM    
Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
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MeSH Terms
Angiotensin II / administration & dosage,  pharmacology*
Blood Pressure / drug effects,  physiology
Dose-Response Relationship, Drug
Injections, Intravenous
Rats, Inbred Strains
Receptors, Angiotensin / physiology
Regional Blood Flow / drug effects
Saralasin / pharmacology
Submandibular Gland / blood supply*,  physiology
Tongue / blood supply,  physiology
Reg. No./Substance:
0/Receptors, Angiotensin; 11128-99-7/Angiotensin II; 34273-10-4/Saralasin

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