| Effects of angiotensin II and aldosterone on diastolic function in vivo in normal man. | |
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MedLine Citation:
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PMID: 7834990 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Doppler echocardiographic indices of diastolic function and systemic haemodynamics were studied in response to infusions of angiotensin II (1, 2, 5 and 10 ng min-1 kg-1), D-aldosterone (2, 4, 10 and 20 ng min-1 kg-1) and placebo [0.9% (w/v) NaCl] in ten normal male subjects. 2. Dose-related increases in systolic and diastolic blood pressure were observed with angiotensin II infusion at rates of 2 ng min-1 kg-1 and above, whereas no changes in blood pressure occurred with D-aldosterone. No changes in aortic stroke distance or heart rate were seen with either angiotensin II or aldosterone infusion. 3. Compared with placebo, angiotensin II infusion produced a dose-related prolongation of the isovolumic relaxation time [mean and 95% confidence intervals 12.0 (8.2-15.8) ms, P < 0.001] at 10 ng min-1 kg-1, and a significant reduction in the ratio between early and late transmitral flow velocity integrals at 2 ng min-1 kg-1, [-0.84 (-1.63 to -0.05), P < 0.05] and 5 ng min-1 kg-1 [-0.76 (-1.47 to -0.05), P < 0.05]. No changes in Doppler echocardiographic indices of diastolic function were observed with D-aldosterone infusion. 4. These data suggest that angiotensin II, even at a sub-pressor concentration, produces an impairment of left ventricular diastolic filling, which occurs independently of its effect on aldosterone release. |
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Authors:
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P B Clarkson; N M Wheeldon; C MacLeod; M Tennent; T M MacDonald |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 87 ISSN: 0143-5221 ISO Abbreviation: Clin. Sci. Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1995-02-28 Completed Date: 1995-02-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 397-401 Citation Subset: IM |
Affiliation:
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University Department of Clinical Pharmacology, Ninewells Hospital, Dundee, Scotland, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / blood, pharmacology* Angiotensin II / blood, pharmacology* Blood Pressure / drug effects Cross-Over Studies Diastole / drug effects* Dose-Response Relationship, Drug Double-Blind Method Echocardiography, Doppler Hemodynamics / drug effects Humans Male |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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