Document Detail

Effects of angiographic contrast media on sino-atrial nodal function.
MedLine Citation:
PMID:  7355     Owner:  NLM     Status:  MEDLINE    
Injection of meglumine diatrizoate (Renografin-76) into the selectively perfused sinus node artery of the dog produces bradycardia which is unaltered by autonomic blockade or by changes in sinus node artery pressure. Contrast agents and other hyperosmolar substances prolong the R-R interval in proportion to their osmolarity. Selective injection of contrast media into other cannulated segments of the coronary tree produces no change in heart rate. Transfemoral arteriography, however, produces bradycardia with both right and left coronary injections. Both direct and reflex sinus node depression occur with coronary arteriography in the dog. Direct effects are mediated by hyperosmolarity.
C W White; D L Eckberg; T Inasaka; F M Abboud
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cardiovascular research     Volume:  10     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-09-25     Completed Date:  1976-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  214-23     Citation Subset:  IM; S    
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology
Atropine / pharmacology
Blood Pressure / drug effects
Diatrizoate / analogs & derivatives*
Diatrizoate Meglumine / pharmacology*
Heart Rate / drug effects*
Osmolar Concentration
Parasympatholytics / pharmacology
Sinoatrial Node / drug effects*
Sodium Chloride
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Parasympatholytics; 117-96-4/Diatrizoate; 131-49-7/Diatrizoate Meglumine; 51-55-8/Atropine; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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