Document Detail

Effects of anger on left ventricular ejection fraction in coronary artery disease.
MedLine Citation:
PMID:  1632389     Owner:  NLM     Status:  MEDLINE    
This study examined the comparative potency of several psychological stressors and exercise in eliciting myocardial ischemia as measured by left ventricular (LV) ejection fraction (EF) changes using radionuclide ventriculography. Twenty-seven subjects underwent both exercise (bicycle) and psychological stressors (mental arithmetic, recall of an incident that elicited anger, giving a short speech defending oneself against a charge of shoplifting) during which EF, blood pressure, heart rate and ST segment were measured. Eighteen subjects had 1-vessel coronary artery disease (CAD), defined by greater than 50% diameter stenosis in 1 artery as assessed by arteriography. Nine subjects served as healthy control subjects. Anger recall reduced EF more than exercise and the other psychological stressors (overall F [3.51] = 2.87, p = .05). Respective changes in EF for the CAD patients were -5% during anger recall, +2% during exercise, 0% during mental arithmetic and 0% during the speech stressor. More patients with CAD had significant reduction in EF (greater than or equal to 7%) during anger (7 of 18) than during exercise (4 of 18). The difference in EF change between patients with CAD and healthy control subjects was significant for both anger (t25 = 2.23, p = 0.04) and exercise (t25 = 2.63, p = 0.01) stressors. In this group of patients with CAD, anger appeared to be a particularly potent psychological stressor.
G Ironson; C B Taylor; M Boltwood; T Bartzokis; C Dennis; M Chesney; S Spitzer; G M Segall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  70     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-08-20     Completed Date:  1992-08-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  281-5     Citation Subset:  AIM; IM    
Department of Psychology, University of Miami, Coral Gables.
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MeSH Terms
Anger / physiology*
Anxiety / physiopathology
Blood Pressure
Coronary Disease / physiopathology,  psychology*,  radionuclide imaging
Exercise Test
Heart Rate
Middle Aged
Myocardial Contraction
Radionuclide Ventriculography
Stress, Psychological / physiopathology
Stroke Volume*
Grant Support
Comment In:
Am J Cardiol. 1993 Feb 15;71(5):500   [PMID:  8430663 ]

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