| Effects of aneuploidy on cellular physiology and cell division in haploid yeast. | |
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MedLine Citation:
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PMID: 17702937 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aneuploidy is a condition frequently found in tumor cells, but its effect on cellular physiology is not known. We have characterized one aspect of aneuploidy: the gain of extra chromosomes. We created a collection of haploid yeast strains that each bear an extra copy of one or more of almost all of the yeast chromosomes. Their characterization revealed that aneuploid strains share a number of phenotypes, including defects in cell cycle progression, increased glucose uptake, and increased sensitivity to conditions interfering with protein synthesis and protein folding. These phenotypes were observed only in strains carrying additional yeast genes, which indicates that they reflect the consequences of additional protein production as well as the resulting imbalances in cellular protein composition. We conclude that aneuploidy causes not only a proliferative disadvantage but also a set of phenotypes that is independent of the identity of the individual extra chromosomes. |
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Authors:
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Eduardo M Torres; Tanya Sokolsky; Cheryl M Tucker; Leon Y Chan; Monica Boselli; Maitreya J Dunham; Angelika Amon |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 317 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-17 Completed Date: 2007-09-05 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 916-24 Citation Subset: IM |
Affiliation:
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Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, 40 Ames Street, Cambridge, MA 02139, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GEO/GSE7812 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aneuploidy* Cell Division Cell Proliferation* Chromosomes, Fungal / genetics G1 Phase Gene Expression Regulation, Fungal Genes, Fungal Glucose / metabolism Haploidy Phenotype Protein Synthesis Inhibitors / pharmacology Saccharomyces cerevisiae / cytology, genetics*, physiology* Saccharomyces cerevisiae Proteins / biosynthesis, metabolism Temperature Transcription, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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GM071508/GM/NIGMS NIH HHS; GM56800/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Protein Synthesis Inhibitors; 0/Saccharomyces cerevisiae Proteins; 50-99-7/Glucose |
| Comments/Corrections | |
Comment In:
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Science. 2007 Aug 17;317(5840):904-5
[PMID:
17702931
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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