| Effects of anesthetics on systemic hemodynamics in mice. | |
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MedLine Citation:
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PMID: 15155266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to compare the systemic hemodynamic effects of four commonly used anesthetic regimens in mice that were chronically instrumented for direct and continuous measurements of cardiac output (CO). Mice (CD-1, Swiss, and C57BL6 strains) were instrumented with a transit-time flow probe placed around the ascending aorta for CO measurement. An arterial catheter was inserted into the aorta 4 or 5 days later for blood pressure measurements. After full recovery, hemodynamic parameters including stroke volume, heart rate, CO, mean arterial pressure (MAP), and total peripheral resistance were measured with animals in the conscious state. General anesthesia was then induced in these mice using isoflurane (Iso), urethane, pentobarbital sodium, or ketamine-xylazine (K-X). The doses and routes of administration of these agents were given as required for general surgical procedures in these animals. Compared with the values obtained for animals in the conscious resting state, MAP and CO decreased during all anesthetic interventions, and hemodynamic effects were smallest for Iso (MAP, -24 +/- 3%; CO, -5 +/- 7%; n = 15 mice) and greatest for K-X (MAP, -51 +/- 6%; CO, -37 +/- 9%; n = 8 mice), respectively. The hemodynamic effects of K-X were fully antagonized by administration of the alpha(2)-receptor antagonist atipamezole (n = 8 mice). These results indicate that the anesthetic Iso has fewer systemic hemodynamic effects in mice than the nonvolatile anesthetics. |
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Authors:
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Ben J A Janssen; Tijl De Celle; Jacques J M Debets; Agnieszka E Brouns; Michael F Callahan; Thomas L Smith |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2004-05-20 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 287 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-16 Completed Date: 2004-11-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1618-24 Citation Subset: IM |
Affiliation:
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Dept. of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, Universiteit Maastricht, PO Box 616, Maastricht 6200 MD, The Netherlands. B.Janssen@farmaco.unimaas.nl |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Anesthesia
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pharmacology Adrenergic alpha-Agonists / pharmacology Adrenergic alpha-Antagonists / pharmacology Analgesics, Opioid / pharmacology Anesthetics, Dissociative / pharmacology Anesthetics, Inhalation / pharmacology* Anesthetics, Intravenous / pharmacology Animals Blood Pressure / drug effects* Buprenorphine / pharmacology Cardiac Output / drug effects* Female Imidazoles / pharmacology Isoflurane / pharmacology* Ketamine / pharmacology Male Mice Mice, Inbred C57BL Pentobarbital / pharmacology Urethane / pharmacology Xylazine / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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HL 55082/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Anesthesia; 0/Adrenergic alpha-Agonists; 0/Adrenergic alpha-Antagonists; 0/Analgesics, Opioid; 0/Anesthetics, Dissociative; 0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Imidazoles; 104054-27-5/atipamezole; 26675-46-7/Isoflurane; 51-79-6/Urethane; 52485-79-7/Buprenorphine; 6740-88-1/Ketamine; 7361-61-7/Xylazine; 76-74-4/Pentobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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