Document Detail

Effects of anesthetics on ponto-geniculo-occipital waves from the oculomotor nucleus of the cat.
MedLine Citation:
PMID:  1130723     Owner:  NLM     Status:  MEDLINE    
Effects of anesthetics and doxapram on pontogeniculo-occipital (PGO) waves from the oculomotor nucleus were studied in acute experiments in cats paralyzed by gallamine triethiodide. The anesthetic agents studied in the present experiment (thiopental, ketamine, Innovar, nitrous oxide, and halothane) decreased, while doxapram increased, the total number of PGO waves. As the doses of anesthetics increased, PGO waves were abolished, but they returned to control levels or below control levels when the concentrations of anesthetics were decreased. The results indicate that the anesthetics studied inhibit the activity of the central mechanism associated with the oculomotor system. PGO waves may prove a useful index of the level of anesthesia.
H Yanagida; N Ashizawa; Y Wakushima; H Yamamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesiology     Volume:  42     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-07-20     Completed Date:  1975-07-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  574-83     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthesia, Inhalation
Anesthetics / pharmacology*
Doxapram / pharmacology
Droperidol / pharmacology
Eye Movements
Fentanyl / pharmacology
Geniculate Bodies / drug effects*
Halothane / pharmacology
Hippocampus / physiology
Ketamine / pharmacology
Nitrous Oxide / pharmacology
Occipital Lobe / drug effects*
Oculomotor Nerve / drug effects,  physiology
Optic Nerve / physiology
Pons / drug effects*
Superior Colliculi / drug effects*,  physiology
Thiopental / pharmacology
Reg. No./Substance:
0/Anesthetics; 10024-97-2/Nitrous Oxide; 151-67-7/Halothane; 309-29-5/Doxapram; 437-38-7/Fentanyl; 548-73-2/Droperidol; 6740-88-1/Ketamine; 76-75-5/Thiopental

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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