Document Detail

Effects of anesthesia on the spontaneous activity of the microvasculature.
MedLine Citation:
PMID:  6480227     Owner:  NLM     Status:  MEDLINE    
The effects of pentobarbital, alpha-chloralose, alphaxalone-alphadolone, diethyl ether and chloralose-urethane anesthesia on microvascular vasomotion were studied in the hamster skin fold window preparation. All these agents paralyzed vasomotion in the arterioles causing an initial vasodilation, where diameters were above the control-unanesthetized mean values (UMD) for a period of 5-60 min and returned to UMD, and lower, after periods up to 90 min depending on the type of anesthetic. During chloralose-urethane anesthesia vasodilation lasted until the end of observation (90 min). The responses were quantitatively different as a function of vessel type, being more pronounced in the smaller terminal arterioles. Vasomotion did not recover at the end of anesthesia, when the animals awoke, and the vessels tended to remain inert for periods up to 10-20 min, at which time the activity was reestablished with the same control fundamental frequency. Small veins and venules did not exhibit vasomotion and showed various reactions that were characteristic for each anesthetic and vessel type, where vasodilation was the prevalent feature during pentobarbital anesthesia while diethyl ether had the opposite effect. Venular microvessels recovered control diameters 10-20 min after awakening.
A Colantuoni; S Bertuglia; M Intaglietta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation     Volume:  3     ISSN:  0167-6865     ISO Abbreviation:  Int J Microcirc Clin Exp     Publication Date:  1984  
Date Detail:
Created Date:  1984-11-14     Completed Date:  1984-11-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8400122     Medline TA:  Int J Microcirc Clin Exp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  13-28     Citation Subset:  IM    
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MeSH Terms
Anesthetics / pharmacology*
Arteries / physiology
Chloralose / pharmacology
Ether, Ethyl / pharmacology
Microcirculation / drug effects,  physiology*
Pentobarbital / pharmacology
Pregnanediones / pharmacology
Urethane / pharmacology
Vasodilation / drug effects
Vasomotor System / drug effects*
Veins / physiology
Venules / physiology
Grant Support
Reg. No./Substance:
0/Anesthetics; 0/Pregnanediones; 14107-37-0/alphadolone; 15879-93-3/Chloralose; 23930-19-0/alphaxalone; 51-79-6/Urethane; 60-29-7/Ether, Ethyl; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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