| Effects of anesthesia on efferent-mediated adaptation of the DPOAE. | |
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MedLine Citation:
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PMID: 12382109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Distortion product otoacoustic emissions (DPOAE) adapt after primary tone onset, with an approximately 100 ms time constant, due to feedback effects of medial olivocochlear (MOC) activity elicited by the primary tones. We tracked DPOAE postonset adaptation as a metric of MOC reflex strength, before during and after induction of anesthesia in guinea pigs. Reflex strength was significantly diminished by the barbiturate/neuroleptic anesthesia most commonly used in this species. The MOC reflex recovered more slowly than toe-pinch or startle reflexes, correlating better with recovery of general mobility. When individual anesthetic agents were assessed, the barbiturate (pentobarbital) significantly diminished MOC reflex strength, whereas fentanyl or droperidol did not. These results suggest that previous studies using anesthetized preparations may have underestimated the magnitude of sound-evoked responses in the OC pathway. |
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Authors:
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K P Boyev; M C Liberman; M C Brown |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. Date: 2002-02-27 |
Journal Detail:
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Title: Journal of the Association for Research in Otolaryngology : JARO Volume: 3 ISSN: 1525-3961 ISO Abbreviation: J. Assoc. Res. Otolaryngol. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-10-16 Completed Date: 2002-12-26 Revised Date: 2011-10-26 |
Medline Journal Info:
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Nlm Unique ID: 100892857 Medline TA: J Assoc Res Otolaryngol Country: United States |
Other Details:
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Languages: eng Pagination: 362-73 Citation Subset: IM |
Affiliation:
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Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological
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physiology* Adjuvants, Anesthesia Analgesics, Opioid Anesthesia* Animals Cochlea / physiology Droperidol Drug Combinations Fentanyl Guinea Pigs Hypnotics and Sedatives Neurons, Efferent / physiology* Olivary Nucleus / physiology Otoacoustic Emissions, Spontaneous* Pentobarbital Perceptual Distortion* Reflex, Acoustic |
| Grant Support | |
ID/Acronym/Agency:
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5 R01 DC00188/DC/NIDCD NIH HHS; R01 DC01089/DC/NIDCD NIH HHS; T32 DC00020/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Anesthesia; 0/Analgesics, Opioid; 0/Drug Combinations; 0/Hypnotics and Sedatives; 437-38-7/Fentanyl; 548-73-2/Droperidol; 76-74-4/Pentobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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