Document Detail


Effects of anesthesia on efferent-mediated adaptation of the DPOAE.
MedLine Citation:
PMID:  12382109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Distortion product otoacoustic emissions (DPOAE) adapt after primary tone onset, with an approximately 100 ms time constant, due to feedback effects of medial olivocochlear (MOC) activity elicited by the primary tones. We tracked DPOAE postonset adaptation as a metric of MOC reflex strength, before during and after induction of anesthesia in guinea pigs. Reflex strength was significantly diminished by the barbiturate/neuroleptic anesthesia most commonly used in this species. The MOC reflex recovered more slowly than toe-pinch or startle reflexes, correlating better with recovery of general mobility. When individual anesthetic agents were assessed, the barbiturate (pentobarbital) significantly diminished MOC reflex strength, whereas fentanyl or droperidol did not. These results suggest that previous studies using anesthetized preparations may have underestimated the magnitude of sound-evoked responses in the OC pathway.
Authors:
K P Boyev; M C Liberman; M C Brown
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2002-02-27
Journal Detail:
Title:  Journal of the Association for Research in Otolaryngology : JARO     Volume:  3     ISSN:  1525-3961     ISO Abbreviation:  J. Assoc. Res. Otolaryngol.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-10-16     Completed Date:  2002-12-26     Revised Date:  2011-10-26    
Medline Journal Info:
Nlm Unique ID:  100892857     Medline TA:  J Assoc Res Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  362-73     Citation Subset:  IM    
Affiliation:
Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / physiology*
Adjuvants, Anesthesia
Analgesics, Opioid
Anesthesia*
Animals
Cochlea / physiology
Droperidol
Drug Combinations
Fentanyl
Guinea Pigs
Hypnotics and Sedatives
Neurons, Efferent / physiology*
Olivary Nucleus / physiology
Otoacoustic Emissions, Spontaneous*
Pentobarbital
Perceptual Distortion*
Reflex, Acoustic
Grant Support
ID/Acronym/Agency:
5 R01 DC00188/DC/NIDCD NIH HHS; R01 DC01089/DC/NIDCD NIH HHS; T32 DC00020/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Adjuvants, Anesthesia; 0/Analgesics, Opioid; 0/Drug Combinations; 0/Hypnotics and Sedatives; 437-38-7/Fentanyl; 548-73-2/Droperidol; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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