| Effects of anesthesia on cardiovascular control mechanisms. | |
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MedLine Citation:
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PMID: 363416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The manner in which general anesthesia affects circulatory control was studied by examining the effects of commonly employed anesthetics on left ventricular function and distribution of cardiac output, and the extent to which responses to physiological and pharmacological stimuli are modified by general anesthesia. While commonly employed anesthetics affect almost every aspect of the circulatory system, the importance of general anesthesia on the circulation tends to be underestimated by considering only its direct effects. More important is the modification of the organism's integrative response to any perturbation. Major differences often directionally opposite, in responses of conscious and anesthetized animals were found for reflex control of the circulation, effects of hemorrhage and alterations in preload and after load. In addition, commonly employed pharmacologic agents, e.g., cardiac glycosdies, catecholamines, and morphine sulfate exerted differing actions in the conscious and anesthetized states. Thus, while it is generally held that the overall responses to complex physiological functions such as exercise or eating can be best described in the intact, conscious organism, the importance of conducting any experiment involving integrative control of the circulation in the conscious organism should also be recognized. |
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Authors:
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S F Vatner |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Environmental health perspectives Volume: 26 ISSN: 0091-6765 ISO Abbreviation: Environ. Health Perspect. Publication Date: 1978 Oct |
Date Detail:
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Created Date: 1979-02-21 Completed Date: 1979-02-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 193-206 Citation Subset: IM; S |
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, General* Animals Blood Pressure / drug effects Coronary Vessels / drug effects, innervation Digitalis Glycosides / pharmacology Halothane / pharmacology Heart Rate / drug effects Hemodynamics / drug effects* Hemorrhage / physiopathology Morphine / pharmacology Myocardial Contraction / drug effects Pentobarbital / pharmacology Reflex Regional Blood Flow / drug effects Sympathomimetics / pharmacology Time Factors Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Digitalis Glycosides; 0/Sympathomimetics; 151-67-7/Halothane; 57-27-2/Morphine; 76-74-4/Pentobarbital |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Environ Health Perspect ISSN: 0091-6765 |
Article Information Download PDF  Print publication date: Month: 10 Year: 1978 Volume: 26First Page: 193 Last Page: 206 ID: 1637240 PubMed Id: 363416 |
| Effects of anesthesia on cardiovascular control mechanisms. | |
| S F Vatner | |
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