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Effects of anesthesia on cardiovascular control mechanisms.
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MedLine Citation:
PMID:  363416     Owner:  NLM     Status:  MEDLINE    
The manner in which general anesthesia affects circulatory control was studied by examining the effects of commonly employed anesthetics on left ventricular function and distribution of cardiac output, and the extent to which responses to physiological and pharmacological stimuli are modified by general anesthesia. While commonly employed anesthetics affect almost every aspect of the circulatory system, the importance of general anesthesia on the circulation tends to be underestimated by considering only its direct effects. More important is the modification of the organism's integrative response to any perturbation. Major differences often directionally opposite, in responses of conscious and anesthetized animals were found for reflex control of the circulation, effects of hemorrhage and alterations in preload and after load. In addition, commonly employed pharmacologic agents, e.g., cardiac glycosdies, catecholamines, and morphine sulfate exerted differing actions in the conscious and anesthetized states. Thus, while it is generally held that the overall responses to complex physiological functions such as exercise or eating can be best described in the intact, conscious organism, the importance of conducting any experiment involving integrative control of the circulation in the conscious organism should also be recognized.
S F Vatner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  26     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1979-02-21     Completed Date:  1979-02-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-206     Citation Subset:  IM; S    
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MeSH Terms
Anesthesia, General*
Blood Pressure / drug effects
Coronary Vessels / drug effects,  innervation
Digitalis Glycosides / pharmacology
Halothane / pharmacology
Heart Rate / drug effects
Hemodynamics / drug effects*
Hemorrhage / physiopathology
Morphine / pharmacology
Myocardial Contraction / drug effects
Pentobarbital / pharmacology
Regional Blood Flow / drug effects
Sympathomimetics / pharmacology
Time Factors
Vascular Resistance / drug effects
Reg. No./Substance:
0/Digitalis Glycosides; 0/Sympathomimetics; 151-67-7/Halothane; 57-27-2/Morphine; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 10 Year: 1978
Volume: 26First Page: 193 Last Page: 206
ID: 1637240
PubMed Id: 363416

Effects of anesthesia on cardiovascular control mechanisms.
S F Vatner

Article Categories:
  • Research Article

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