| Effects of anemia correction by erythropoiesis-stimulating agents on cardiovascular function in non-dialysis patients with chronic kidney disease. | |
| | |
MedLine Citation:
|
PMID: 22878802 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Anemia is a significant risk factor for patients with chronic kidney disease (CKD). Here, we investigated the effects of anemia correction on cardiac functions in CKD patients. Pre-dialysis CKD patients (n = 171) without known risk factors for cardiovascular disease (CVD) other than CKD with hemoglobin (Hb) concentrations < 10.0 g/dL were enrolled for evaluation of cardiac functions and biomarkers before and after the 16-week treatment of erythropoiesis-stimulating agents. The treatment significantly increased Hb concentrations in all patients who completed the study (n = 143, 8.91 ± 0.87 versus 11.27 ± 1.31 g/dL; n < 0.001) and among patients whose echocardiograms were available for evaluation (n = 77, 8.92 ± 0.94 versus 11.24 ± 1.13 g/dL; P < 0.001). The left ventricular mass index (LVMI) was decreased (121.3 ± 25.8 versus 114.7 ± 25.1 g/m<sup>2</sup>, n = 77, P = 0.012) and significant correlation between the change in the LVMI and Hb concentration was noted (P = 0.011). The levels of B-type natriuretic peptide and human atrial natriuretic peptide, and the cardio-thoracic ratio were significantly increased among subjects with Hb concentrations < 11.0 g/dL at completion of the study. The changes in these parameters were significantly correlated with the Hb concentrations (P = 0.033, P = 0.011, and P < 0.001, respectively). No significant differences were observed in the electrocardiographic parameters. Correcting Hb levels higher than those conventionally recommended reduced left ventricular hypertrophy and myocardial stress, lowering risks for CVD in pre-dialysis CKD patients. |
| | |
Authors:
|
Makoto Suzuki; Yoshiyuki Hada; Makoto Akaishi; Michiaki Hiroe; Kazutaka Aonuma; Yoshiharu Tsubakihara; Tadao Akizawa |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International heart journal Volume: 53 ISSN: 1349-3299 ISO Abbreviation: Int Heart J Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-08-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101244240 Medline TA: Int Heart J Country: Japan |
Other Details:
|
Languages: eng Pagination: 238-43 Citation Subset: IM |
Affiliation:
|
Department of Clinical Laboratory, Toho University Ohashi Medical Center. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Correlation between serum concentrations of B-type natriuretic Peptide and albumin in patients with ...
Next Document: Combination of Antihypertensive Therapy in The Elderly, Multicenter Investigation (CAMUI) Trial.