Document Detail

Effects of an androgenic steroid on exercise-induced cardiac remodeling in rats.
MedLine Citation:
PMID:  10658005     Owner:  NLM     Status:  MEDLINE    
Habitual exercise results in a rightward shift in left ventricular end diastolic (LVED) pressure-volume or internal dimension (P-D) relationships [left ventricular (LV) remodeling]. However, exercise-mediated LV hypertrophy (LVH) produces an increased LV relative wall thickness [ratio (h/r) of wall thickness (h) to internal radius (r)] and hence a decrement in diastolic wall stress despite LV remodeling. In this study, the effect of chronic administration of an androgenic steroid on exercise-induced LV remodeling and h/r was examined in rats. Habitual exercise on voluntary running wheels resulted in LVH and a rightward shift in the LVED P-D relationships. However, LVH was sufficient to increase LVED h/r. Androgenic steroid administration to exercised rats, without influencing the development of exercise-induced LVH, produced a further rightward shift in the LVED P-D relationship associated with an increased diameter intercept. As a consequence, LVED h/r was reduced to control values. The steroid-mediated effects were not associated with alterations in either the quantity or quality of LV collagen. In conclusion, high-dose androgenic steroid administration alters exercise-induced LV remodeling and subsequently reduces the beneficial effect of physiological LVH on LV h/r.
A J Woodiwiss; B Trifunovic; M Philippides; G R Norton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  88     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-03     Completed Date:  2000-03-03     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  409-15     Citation Subset:  IM; S    
Laboratory of Cardiovascular Pathophysiology, Department of Physiology, University of the Witwatersrand, 2193 Johannesburg, South Africa.
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MeSH Terms
Anabolic Agents / pharmacology*
Collagen / drug effects,  metabolism
Heart / anatomy & histology
Heart Ventricles / anatomy & histology,  drug effects,  metabolism
Organ Size / drug effects
Physical Conditioning, Animal / physiology*
Rats, Sprague-Dawley
Stroke Volume / drug effects,  physiology
Testosterone Congeners / pharmacology*
Ventricular Function, Left / drug effects,  physiology
Ventricular Remodeling / drug effects*,  physiology
Reg. No./Substance:
0/Anabolic Agents; 0/Testosterone Congeners; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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