| Effects of androgen on vascular and inflammatory biomarkers in a female hypertensive population. | |
| | |
MedLine Citation:
|
PMID: 23327657 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Abstract Background: Androgen is a steroid hormone associated with high blood pressure (BP). The effect of androgen on BP in females is unknown. Methods: Androgen, vascular endothelial growth factor (VEGF), interleukin (IL)-6 and matrix metalloproteinase (MMP)-9 were evaluated in females with menstruation disorders (n = 135, 28 ± 5 years old) and normal BP, pre-hypertension, stage 1 hypertension, and stage 2 hypertension. Results: Normal-BP (n = 57), pre-hypertension (n = 44), stage-1-hypertension (n = 21), and stage-2-hypertension (n = 13) females had similar androgen (3.3 ± 1.5, 2.7 ± 1.2, 3.1 ± 1.4, and 3.5 ± 1.3 ng/ml, p > 0.05) and IL-6 levels (1.7 ± 2.2, 1.9 ± 2.6, 1.3 ± 1.2 and 2.4 ± 3.3 pg/ml, p > 0.05). However, normal BP females had lower MMP-9 (609 ± 307 versus 891 ± 385 ng/ml, p < 0.05) than stage-1-hypertension females. In addition, normal BP females had lower VEGF (166 ± 103 versus 255 ± 139, 272 ± 128 and 301 ± 216 pg/ml, p < 0.05) than the other three groups. In normal-androgen females, VEGF levels were similar among the four groups. However, in high-androgen females, normal BP groups had lower VEGF levels than pre-hypertension, stage-1, and stage-2 hypertension groups (166 ± 94 versus 294 ± 153, 281 ± 160 and 357 ± 253 p < 0.05). Conclusions: Androgen can modulate growth factors and extracellular matrix proteins, which may contribute to the pathophysiology of hypertension in young females. |
| | |
Authors:
|
Jen-Hung Huang; Wan-Chun Chiu; Ming-I Hsu; Yi-Jen Chen |
Related Documents
:
|
3107517 - Arterial regeneration over polydioxanone prostheses in the rabbit. 7256277 - Elastic arteries in invertebrates: mechanics of the octopus aorta. 22837287 - New approach to intracardiac hemodynamic measurements in small animals: echo-guided per... 18386607 - Renovascular hypertension in children: symptoms and manifestations. a 19 patients clini... 2221127 - Activity of canine in situ left atrial ganglion neurons. 9374947 - Patterns of compliance with once versus twice daily antihypertensive drug therapy in pr... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-18 |
Journal Detail:
|
Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: - ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University , Taipei , Taiwan . |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Selective Inhibition of Extracellular Thioredoxin by Asymmetric Disulfides.
Next Document: Dialkoxybithiazole: A New Building Block for Head-to-Head Polymer Semiconductors.