Document Detail


Effects of androgen on vascular and inflammatory biomarkers in a female hypertensive population.
MedLine Citation:
PMID:  23327657     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Background: Androgen is a steroid hormone associated with high blood pressure (BP). The effect of androgen on BP in females is unknown. Methods: Androgen, vascular endothelial growth factor (VEGF), interleukin (IL)-6 and matrix metalloproteinase (MMP)-9 were evaluated in females with menstruation disorders (n = 135, 28 ± 5 years old) and normal BP, pre-hypertension, stage 1 hypertension, and stage 2 hypertension. Results: Normal-BP (n = 57), pre-hypertension (n = 44), stage-1-hypertension (n = 21), and stage-2-hypertension (n = 13) females had similar androgen (3.3 ± 1.5, 2.7 ± 1.2, 3.1 ± 1.4, and 3.5 ± 1.3 ng/ml, p > 0.05) and IL-6 levels (1.7 ± 2.2, 1.9 ± 2.6, 1.3 ± 1.2 and 2.4 ± 3.3 pg/ml, p > 0.05). However, normal BP females had lower MMP-9 (609 ± 307 versus 891 ± 385 ng/ml, p < 0.05) than stage-1-hypertension females. In addition, normal BP females had lower VEGF (166 ± 103 versus 255 ± 139, 272 ± 128 and 301 ± 216 pg/ml, p < 0.05) than the other three groups. In normal-androgen females, VEGF levels were similar among the four groups. However, in high-androgen females, normal BP groups had lower VEGF levels than pre-hypertension, stage-1, and stage-2 hypertension groups (166 ± 94 versus 294 ± 153, 281 ± 160 and 357 ± 253 p < 0.05). Conclusions: Androgen can modulate growth factors and extracellular matrix proteins, which may contribute to the pathophysiology of hypertension in young females.
Authors:
Jen-Hung Huang; Wan-Chun Chiu; Ming-I Hsu; Yi-Jen Chen
Related Documents :
3107517 - Arterial regeneration over polydioxanone prostheses in the rabbit.
7256277 - Elastic arteries in invertebrates: mechanics of the octopus aorta.
23936377 - Effects of acute exposure to moderate altitude on vascular function, metabolism and sys...
22837287 - New approach to intracardiac hemodynamic measurements in small animals: echo-guided per...
24621657 - Prognostic value of pulmonary hypertension in ambulatory patients with non-ischemic dil...
2221127 - Activity of canine in situ left atrial ganglion neurons.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-18
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  -     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University , Taipei , Taiwan .
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Selective inhibition of extracellular thioredoxin by asymmetric disulfides.
Next Document:  Dialkoxybithiazole: A New Building Block for Head-to-Head Polymer Semiconductors.