Document Detail

Effects of anaesthesia on regional coronary control mechanisms.
MedLine Citation:
PMID:  11117226     Owner:  NLM     Status:  MEDLINE    
1. The regional coronary circulation is under the control of local metabolic and myogenic factors, but is also influenced by autonomic systems, including sympathetic and parasympathetic nerves. 2. General anaesthetic agents influence not only local control through changes in metabolic demand, but also neural control through suppression of autonomic influence. 3. Anaesthetic agents have differing effects on reflex control systems, which are dependent on coronary territory and ventricular rate. 4. Effects of anaesthesia should be taken into account when interpreting results in anaesthetized models of coronary control.
D B Cottee; A W Quail; W L Porges; P G Moore; S W White
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  27     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-14     Completed Date:  2000-12-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1034-8     Citation Subset:  IM    
Division of Anaesthesia and Intensive Care, John Hunter Hospital, Newcastle, Australia.
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MeSH Terms
Anesthetics, Inhalation / pharmacology*
Blood Pressure / drug effects
Chemoreceptor Cells
Coronary Circulation / physiology*
Enflurane / pharmacology*
Halothane / pharmacology*
Heart Rate / drug effects
Isoflurane / pharmacology*
Receptors, Cholinergic / physiology
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Receptors, Cholinergic; 13838-16-9/Enflurane; 151-67-7/Halothane; 26675-46-7/Isoflurane

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