Document Detail

Effects of amphiphilic star-shaped poly(ethylene glycol) polymers with a cholic acid core on human red blood cell aggregation.
MedLine Citation:
PMID:  23262308     Owner:  NLM     Status:  MEDLINE    
Elevated red blood cell (RBC) aggregation increases low-shear blood viscosity and is closely related to several pathophysiological diseases such as atherosclerosis, thrombosis, diabetes, hypertension, cancer, and hereditary chronic hemolytic conditions. Non-ionic linear polymers such as poly(ethylene glycol) (PEG) and Pluronic F68 have shown inhibitory effects against RBC aggregation. However, hypersensitivity reactions in some individuals, attributed to a diblock component of Pluronic F68, have been reported. Therefore, we investigated the use of an amphiphilic star-shaped PEG polymer based on a cholic acid core as a substitute for Pluronics to reduce RBC aggregation. Cholic acid is a natural bile acid produced in the human liver and therefore should assure biocompatibility. Cholic acid based PEG polymers, termed CA(PEG)(4), were synthesized by anionic polymerization. Size exclusion chromatography indicated narrow mass distributions and hydrodynamic radii less than 2 nm were calculated. The effects of CA(PEG)(4) on human RBC aggregation and blood viscosity were investigated and compared to linear PEGs by light transmission aggregometry. Results showed optimal reduction of RBC aggregation for molar masses between 10 and 16 kDa of star-shaped CA(PEG)(4) polymers. Cholic acid based PEG polymers affect the rheology of erythrocytes and may find applications as alternatives to linear PEG or Pluronics to improve blood fluidity.
Florence Janvier; Julian X X Zhu; Jonathan Armstrong; Herbert J Meiselman; Guy Cloutier
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-27
Journal Detail:
Title:  Journal of the mechanical behavior of biomedical materials     Volume:  18     ISSN:  1878-0180     ISO Abbreviation:  J Mech Behav Biomed Mater     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-07-19     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  101322406     Medline TA:  J Mech Behav Biomed Mater     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  100-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Cholic Acid / chemistry*
Erythrocyte Aggregation / drug effects*
Hydrophobic and Hydrophilic Interactions*
Polyethylene Glycols / chemical synthesis,  chemistry*,  pharmacology*
Structure-Activity Relationship
Grant Support
CMI-72323//Canadian Institutes of Health Research; R01 HL078655/HL/NHLBI NIH HHS; R01HL078655/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Polyethylene Glycols; G1JO7801AE/Cholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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