Document Detail


Effects of amphetamine, dexfenfluramine, and diazepam on responding during extinction in nonhuman primates.
MedLine Citation:
PMID:  15501309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of pharmacological manipulations on responding under extinction conditions were determined in baboons using a schedule of reinforcement that modeled food acquisition and food consumption. Responding during the initial acquisition component was reinforced by stimuli paired with food, while responding during the latter consumption component was reinforced with food. Certain sessions began with a 7-h extinction phase, where responding in both components produced only the paired stimuli. Dexfenfluramine (DFEN) decreased responding during extinction. Diazepam (DZP) increased responding during extinction. Low doses of amphetamine (AMPH) increased responding during extinction. Thus, DZP and AMPH increased and DFEN decreased the conditioned reinforcing effects of stimuli paired with food.
Authors:
Richard W Foltin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  79     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-25     Completed Date:  2005-04-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  325-30     Citation Subset:  IM    
Affiliation:
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA. rwf2@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Dexfenfluramine / administration & dosage,  pharmacology*
Dextroamphetamine / administration & dosage,  pharmacology*
Diazepam / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Eating / drug effects
Extinction, Psychological / drug effects*
Male
Papio cynocephalus
Reinforcement (Psychology)
Grant Support
ID/Acronym/Agency:
DA-04130/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
3239-44-9/Dexfenfluramine; 439-14-5/Diazepam; 51-64-9/Dextroamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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