Document Detail

Effects of amphetamine, dexfenfluramine, diazepam, and other pharmacological and dietary manipulations on food "seeking" and "taking" behavior in non-human primates.
MedLine Citation:
PMID:  11685381     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Feeding consists of appetitive or foraging behavior followed by consummatory behavior. OBJECTIVES: To determine if pharmacological manipulations can differentially affect appetitive and consummatory aspects of food intake, and to compare these results to those obtained using naturalistic dietary manipulations. METHODS: Responding of baboons was studied using a schedule of reinforcement that simulated food "seeking" and food "taking." Responding during the seeking component was reinforced by stimuli paired with food, while responding during the taking component was reinforced with food. The effects of intramuscular amphetamine (AMPH), dexfenfluramine (DFEN), diethylpropion (DEP), phencyclidine (PCP), diazepam (DZP), as well as caloric prefeeding and acute food deprivation were determined. RESULTS: AMPH decreased food taking and increased food seeking, DEP decreased food taking without affecting food seeking, DFEN and PCP decreased both food taking and food seeking, while DZP increased both food taking and food seeking. Caloric prefeeding decreased food taking and increased food seeking, i.e., resembled AMPH, while acute deprivation increased both food taking and food seeking, i.e., resembled DZP. CONCLUSIONS: Manipulations that increase dopamine turnover, such as AMPH, increase food seeking, while decreasing food intake. In contrast, manipulations that increase serotonin turnover, such as DFEN, decrease both food seeking and food taking.
R W Foltin
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychopharmacology     Volume:  158     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-30     Completed Date:  2002-01-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  28-38     Citation Subset:  IM    
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, Unit 120, New York, NY 10032, USA.
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MeSH Terms
Amphetamine / pharmacology*
Anti-Anxiety Agents / pharmacology*
Appetitive Behavior / drug effects,  physiology
Central Nervous System Stimulants / pharmacology*
Dexfenfluramine / pharmacology*
Diazepam / pharmacology*
Feeding Behavior / drug effects*,  physiology
Reinforcement Schedule
Serotonin Agonists / pharmacology*
Grant Support
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Central Nervous System Stimulants; 0/Serotonin Agonists; 300-62-9/Amphetamine; 3239-44-9/Dexfenfluramine; 439-14-5/Diazepam

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