Document Detail


Effects of amosulalol, a combined alpha 1- and beta-adrenoceptor-blocking agent, on ischemic myocardial energy metabolism in dogs.
MedLine Citation:
PMID:  8095542     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of amosulalol, a combined alpha 1- and beta-adrenoceptor-blocking agent, on changes in myocardial energy and carbohydrate metabolism during ischemia was studied. Ischemia was induced by ligating the left anterior descending coronary artery for 3 or 30 min during open-chest surgery in anesthetized dogs. The myocardial energy stores were depleted, and the levels of glycolytic intermediates were altered by 3 and 30 min of ischemia, indicating that anaerobic myocardial metabolism had occurred. Amosulalol (0.3 or 1 mg.kg-1) was injected intravenously 5 min before ischemia. Pretreatment with amosulalol, particularly at a dose of 0.3 mg.kg-1, reduced the myocardial energy depletion and the alteration of carbohydrate metabolism induced by ischemia. This result indicates that amosulalol can reduce ischemic influences on the myocardium.
Authors:
N Hayase; K Chiba; K Ichihara
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  82     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-15     Completed Date:  1993-04-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  291-5     Citation Subset:  IM    
Affiliation:
Department of Hospital Pharmacy, Asahikawa Medical College, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate / metabolism
Adenosine Triphosphate / metabolism
Adrenergic alpha-Antagonists / antagonists & inhibitors
Adrenergic beta-Antagonists / antagonists & inhibitors
Animals
Blood Pressure / drug effects
Dogs
Dose-Response Relationship, Drug
Energy Metabolism / drug effects*
Ethanolamines / pharmacology*
Female
Fructosephosphates / metabolism
Glucose-6-Phosphate
Glucosephosphates / metabolism
Heart Rate / drug effects
Male
Myocardial Ischemia / drug therapy,  metabolism*
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Ethanolamines; 0/Fructosephosphates; 0/Glucosephosphates; 56-65-5/Adenosine Triphosphate; 56-73-5/Glucose-6-Phosphate; 58-64-0/Adenosine Diphosphate; 6814-87-5/fructose-6-phosphate; 70958-86-0/amosulalol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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