Document Detail


Effects of amlodipine and valsartan on vascular damage and ambulatory blood pressure in untreated hypertensive patients.
MedLine Citation:
PMID:  16810279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was performed to compare the long-term effects of 24-h ambulatory blood pressure (BP) control with amlodipine versus valsartan on vascular damage in untreated hypertensive patients. Amlodipine and valsartan have benefits on cardiovascular mortality and morbidity in hypertensive patients. Although ambulatory BP is associated with severity of target-organ damage in hypertensive patients, beneficial effects of ambulatory BP control with amlodipine versus valsartan on vascular damage have not been compared. Pulse wave velocity (PWV), intima-media thickness (IMT) of the carotid arteries, urinary albumin excretion (UAE) and 24-h ambulatory BP were determined in 100 untreated hypertensive patients before and 12 months after the start of antihypertensive therapy with amlodipine or valsartan. Amlodipine and valsartan decreased ambulatory BP similarly, but the variability of 24-h and daytime ambulatory systolic BP was significantly reduced by amlodipine but not by valsartan. The reduced variability of ambulatory systolic BP caused by amlodipine significantly contributed to the improvement of PWV, although both drugs decreased PWV similarly. Carotid IMT was unaffected by treatment with either drug. Valsartan significantly decreased UAE independently of its depressor effect, but amlodipine had no effect on UAE. These results suggest that the 24-h control of ambulatory BP with amlodipine had functionally improved the stiffened arteries of hypertensive patients by the end of 12 months of treatment, in part through reducing BP variability, whereas ambulatory BP control with valsartan decreased the arterial stiffness to the same degree as amlodipine without affecting BP variability maybe through some pleiotropic effects.
Authors:
A Ichihara; Y Kaneshiro; T Takemitsu; M Sakoda
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-06-29
Journal Detail:
Title:  Journal of human hypertension     Volume:  20     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-21     Completed Date:  2006-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  787-94     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. atzichi@sc.itc.keio.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Amlodipine / administration & dosage*
Antihypertensive Agents / administration & dosage*
Blood Pressure / drug effects*
Blood Pressure Monitoring, Ambulatory
Carotid Arteries / physiopathology*
Endothelium, Vascular / injuries,  physiopathology
Female
Humans
Hypertension / drug therapy*,  mortality,  physiopathology,  urine
Male
Middle Aged
Pulse
Tetrazoles / administration & dosage*
Valine / administration & dosage,  analogs & derivatives*
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Tetrazoles; 137862-53-4/valsartan; 7004-03-7/Valine; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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