Document Detail

Effects of amlodipine plus atorvastatin association in hypertensive hypercholesterolemic patients.
MedLine Citation:
PMID:  20528641     Owner:  NLM     Status:  MEDLINE    
Therapies that lower blood pressure or lipid levels slow the progression of atherosclerosis, and reduce morbidity and mortality in patients with hypertension or atherosclerotic disease. A combination tablet containing both amlodipine besylate and atorvastatin calcium has recently been approved for the treatment of hypertension and dyslipidemia in a growing number of countries. We decided to undertake a thorough literature search to evaluate the effects of amlodipine and atorvastatin in hypertensive hypercholesterolemic patients on blood pressure values, lipid profile values and, when available, data on small- and large-artery compliance, left ventricular mass index, and inflammatory parameters. From the data collected, it emerged that in hypertensive and hypercholesterolemic patients, the combination of amlodipine plus atorvastatin is more effective than the single drugs alone in reducing blood pressure and in improving lipid profile. Furthermore the combination of amlodipine plus atorvastatin also improved small-artery compliance, inflammatory markers, left ventricular hypertrophy and reduced uric acid faster and more effectively than the single drugs taken alone. For these reasons, the combination of amlodipine plus atorvastatin could be the treatment of choice in hypertensive and hypercholesterolemic patients.
Giuseppe Derosa; Pamela Maffioli
Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Expert review of cardiovascular therapy     Volume:  8     ISSN:  1744-8344     ISO Abbreviation:  Expert Rev Cardiovasc Ther     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-09     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101182328     Medline TA:  Expert Rev Cardiovasc Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  835-43     Citation Subset:  IM    
Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.
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MeSH Terms
Amlodipine / adverse effects,  therapeutic use*
Antihypertensive Agents / adverse effects,  therapeutic use*
Antilipemic Agents / adverse effects,  therapeutic use*
Biological Markers / blood
Blood Pressure / drug effects
Cardiovascular Diseases / prevention & control
Drug Combinations
Drug Therapy, Combination / adverse effects
Heptanoic Acids / adverse effects,  therapeutic use*
Hypercholesterolemia / blood,  drug therapy*
Hypertension / blood,  drug therapy*
Pyrroles / adverse effects,  therapeutic use*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Antilipemic Agents; 0/Biological Markers; 0/Drug Combinations; 0/Heptanoic Acids; 0/Pyrroles; 110862-48-1/atorvastatin; 88150-42-9/Amlodipine

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