| Effects of amlodipine on platelet aggregation and blood pressure in patients with essential hypertension. | |
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MedLine Citation:
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PMID: 8519039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ten patients (mean age, 46 years) with mild to moderate hypertension received 5 mg of amlodipine daily for 12 weeks. The amlodipine dose was increased to 10 mg daily in 4 patients whose blood pressure remained > or = 90 mmHg during the first 8 weeks. After 8 and 12 weeks of treatment, mean blood pressures in the supine, sitting, and standing positions and after exercise were reduced significantly. Heart rate did not change significantly from before to after treatment. Six hours after amlodipine administration, however, slight but significant increases in heart rate were noted at rest and after exercise. Platelet aggregation induced by adenosine diphosphate or collagen was significantly reduced 6 hours after amlodipine. One patient reported headache after the 10-mg dose of amlodipine. No other side effects were noted. It is concluded that 10 mg of amlodipine once daily is safe and effective in the treatment of mild to moderate hypertension. |
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Authors:
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R Hernández; A R Carvajal; M J Armas-de Hernandez; J Guerrero-Pajuelo; M C Armas-Padilla; O Barragan; I Machado-de Alvarado |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical therapeutics Volume: 15 ISSN: 0149-2918 ISO Abbreviation: Clin Ther Publication Date: 1993 Mar-Apr |
Date Detail:
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Created Date: 1993-07-26 Completed Date: 1993-07-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7706726 Medline TA: Clin Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 304-13 Citation Subset: IM |
Affiliation:
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Clinical Pharmacology Unit, School of Medicine, Universidad Centro Occidental Lisandro Alvarado, Barquisimeto, Venezuela. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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pharmacology Adult Aged Amlodipine / pharmacology*, therapeutic use Blood Pressure / drug effects* Exercise Female Heart Rate / drug effects Humans Hypertension / drug therapy, physiopathology* Male Middle Aged Platelet Aggregation / drug effects* Posture Rest Single-Blind Method |
| Chemical | |
Reg. No./Substance:
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58-64-0/Adenosine Diphosphate; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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