Document Detail


Effects of amlodipine, a long-acting dihydropyridine calcium antagonist in aging hypertension: pharmacodynamics in relation to disposition.
MedLine Citation:
PMID:  2142447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pharmacodynamics and disposition of amlodipine, a dihydropyridine calcium antagonist, were compared between elderly and young patients with hypertension. Elderly (mean +/- SD; age, 68 +/- 3 years) and young (35 +/- 5 years) patients received single intravenous amlodipine doses followed by oral administration once daily for a total of 12 weeks. After intravenous administration, elderly patients had prolonged elimination half-life values (58 +/- 11 versus 42 +/- 8 hours; p less than 0.01) caused by decreased clearance (19 +/- 5 versus 25 +/- 7 L/hr; p less than 0.01). After a 3-months oral treatment washout period, half-life tended to be prolonged in the elderly patients (69 +/- 20 hours for the elderly patients versus 53 +/- 14 hours for the young patients; difference not significant) and was not markedly different from the short-term intravenous measurement. Both systolic and diastolic blood pressure were significantly decreased from baseline throughout the treatment period, with greater decreases in elderly patients for both systolic and diastolic pressure. When amlodipine plasma concentration was correlated to change in mean blood pressure after short-term intravenous doses, elderly patients had a greater decrease than young patients at a given drug concentration. However, after long-term oral administration, elderly and young patients had comparable decreases in mean blood pressure at a given drug concentration, and the increased antihypertensive effect in the elderly was associated with somewhat higher amlodipine plasma concentration. Amlodipine administered once daily is an effective antihypertensive agent in elderly patients and young patients with essential hypertension.
Authors:
D R Abernethy; J Gutkowska; L M Winterbottom
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  48     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-22     Completed Date:  1990-08-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  76-86     Citation Subset:  AIM; IM    
Affiliation:
Division of Clinical Pharmacology, Brown University, Providence, RI 02908.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Aged
Aging / physiology*
Amlodipine
Atrial Natriuretic Factor / analysis
Blood Pressure / drug effects
Calcium Channel Blockers / administration & dosage,  pharmacokinetics,  pharmacology*
Catecholamines / analysis
Female
Heart Rate / drug effects
Humans
Hypertension / metabolism,  physiopathology*
Injections, Intravenous
Male
Middle Aged
Nifedipine / administration & dosage,  analogs & derivatives*,  pharmacokinetics,  pharmacology
Renin-Angiotensin System / drug effects
Grant Support
ID/Acronym/Agency:
AG-08226/AG/NIA NIH HHS; RR-02038-06/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Catecholamines; 21829-25-4/Nifedipine; 85637-73-6/Atrial Natriuretic Factor; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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