Document Detail

Effects of amlodipine in patients with chronic heart failure.
MedLine Citation:
PMID:  9398099     Owner:  NLM     Status:  MEDLINE    
The role of calcium antagonists in patients with ischemic heart failure is currently unclear. We examined the effects of amlodipine on exercise capacity and central and regional hemodynamics in 32 patients with mild to moderate chronic heart failure in a single-center, double-blind, randomized placebo-controlled trial. All were taking at least 40 mg of furosemide daily with an angiotensin-converting enzyme inhibitor. Ischemic heart disease was the most common cause of heart failure, but no patient had symptom-limiting angina. Mean treadmill exercise capacity in patients taking amlodipine increased by 96 seconds (95% confidence interval -23 to 215) and 50 seconds (-34 to 135) in the placebo group; mean difference in change between treatments was 70 seconds (-90 to 233), p = 0.38. Active treatment with amlodipine did not affect self-paced corridor walking times. Similarly, there were no significant effects on cardiac output, oxygen uptake, heart rate, and mean arterial pressure at rest or during exercise. Calf and renal blood flow were also unchanged by treatment. The lack of significant effect demonstrated by these data suggests a limited role for amlodipine in patients with ischemic cardiomyopathy, although it may prove beneficial in those with nonischemic disease. More data are required before amlodipine can be recommended for all patients with chronic heart failure.
J T Walsh; R Andrews; S Curtis; A Evans; A J Cowley
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  134     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-31     Completed Date:  1997-12-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  872-8     Citation Subset:  AIM; IM    
Department of Cardiology, Papworth Hospital, Papworth Everard, Cambridge, United Kingdom.
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MeSH Terms
Amlodipine / pharmacology*
Calcium Channel Blockers / pharmacology*
Chronic Disease
Double-Blind Method
Exercise Test
Exercise Tolerance
Heart Failure / drug therapy*,  physiopathology
Hemodynamics / drug effects
Middle Aged
Oxygen Consumption / drug effects
Prospective Studies
Treatment Outcome
Reg. No./Substance:
0/Calcium Channel Blockers; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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