Document Detail


Effects of amlodipine on circadian rhythms in blood pressure, heart rate, and motility: a telemetric study in rats.
MedLine Citation:
PMID:  1839243     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In male Wistar rats [light(L): 07:00-19:00 h, dark(D): 19:00-07:00 h], the effects of the calcium channel blocker amlodipine (1, 3, 10 mg/kg i.p.) on blood pressure, heart rate, and motor activity were studied by telemetric monitoring. Amlodipine was injected either at 07:00 h or at 19:00 h. Systolic and diastolic blood pressure were dose-dependently decreased with more pronounced effects in the dark span, ED50 values in D were about seven times lower than in L. In contrast, the dose-dependent increase in heart rate was more pronounced in L than in D. No significant effects of amlodipine were found on motor activity. The study gives evidence for a circadian phase-dependency in the cardiovascular effects amlodipine in rats.
Authors:
A Mattes; B Lemmer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chronobiology international     Volume:  8     ISSN:  0742-0528     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  1991  
Date Detail:
Created Date:  1992-04-22     Completed Date:  1992-04-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  526-38     Citation Subset:  IM    
Affiliation:
Zentrum der Pharmakologie, J. W. Goethe Universität, Frankfurt, Germany.
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MeSH Terms
Descriptor/Qualifier:
Amlodipine
Animals
Blood Pressure / drug effects,  physiology
Calcium Channel Blockers / administration & dosage,  pharmacology
Circadian Rhythm / drug effects*,  physiology
Dose-Response Relationship, Drug
Drug Administration Schedule
Heart Rate / drug effects,  physiology
Male
Motor Activity / drug effects,  physiology
Nifedipine / administration & dosage,  analogs & derivatives*,  pharmacology
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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