| Effects of amlodipine on circadian rhythms in blood pressure, heart rate, and motility: a telemetric study in rats. | |
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MedLine Citation:
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PMID: 1839243 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In male Wistar rats [light(L): 07:00-19:00 h, dark(D): 19:00-07:00 h], the effects of the calcium channel blocker amlodipine (1, 3, 10 mg/kg i.p.) on blood pressure, heart rate, and motor activity were studied by telemetric monitoring. Amlodipine was injected either at 07:00 h or at 19:00 h. Systolic and diastolic blood pressure were dose-dependently decreased with more pronounced effects in the dark span, ED50 values in D were about seven times lower than in L. In contrast, the dose-dependent increase in heart rate was more pronounced in L than in D. No significant effects of amlodipine were found on motor activity. The study gives evidence for a circadian phase-dependency in the cardiovascular effects amlodipine in rats. |
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Authors:
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A Mattes; B Lemmer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chronobiology international Volume: 8 ISSN: 0742-0528 ISO Abbreviation: Chronobiol. Int. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-04-22 Completed Date: 1992-04-22 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8501362 Medline TA: Chronobiol Int Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 526-38 Citation Subset: IM |
Affiliation:
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Zentrum der Pharmakologie, J. W. Goethe Universität, Frankfurt, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amlodipine Animals Blood Pressure / drug effects, physiology Calcium Channel Blockers / administration & dosage, pharmacology Circadian Rhythm / drug effects*, physiology Dose-Response Relationship, Drug Drug Administration Schedule Heart Rate / drug effects, physiology Male Motor Activity / drug effects, physiology Nifedipine / administration & dosage, analogs & derivatives*, pharmacology Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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