Document Detail


Effects of amitriptyline on diurnal variations of oxidation-reduction enzyme activities in rat lymphocytes during experimental desynchronosis.
MedLine Citation:
PMID:  11550063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effects of amitriptyline on diurnal variations of oxidative-reduction enzyme activities (succinate dehydrogenase, lactate dehydrogenase, and NADPH diaphorase) in rat peripheral blood lymphocytes during experimental desynchronosis. Desynchronosis was induced by constant light exposure for 14 days and manifested in a morning shift of maximum lactate dehydrogenase activity and elevated morning NADPH diaphorase activity. Amitriptyline normalized morning lactate dehydrogenase activity and diurnal variations in NADPH diaphorase activity.
Authors:
G I Litvinenko; A V Shurlygina; V A Trufakin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  131     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-09-10     Completed Date:  2002-03-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  490-2     Citation Subset:  IM    
Affiliation:
Institute of Clinical and Experimental Lymphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
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MeSH Terms
Descriptor/Qualifier:
Amitriptyline / pharmacology*
Animals
Circadian Rhythm
Cortical Synchronization
L-Lactate Dehydrogenase / blood
Light
Lymphocytes / enzymology*
Male
NADPH Dehydrogenase / blood
Oxidation-Reduction*
Rats
Rats, Wistar
Succinate Dehydrogenase / blood
Time Factors
Chemical
Reg. No./Substance:
50-48-6/Amitriptyline; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.3.99.1/Succinate Dehydrogenase; EC 1.6.99.1/NADPH Dehydrogenase

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