Document Detail

Effects of amisulpride and aripiprazole on progressive-ratio schedule performance: comparison with clozapine and haloperidol.
MedLine Citation:
PMID:  21969105     Owner:  NLM     Status:  MEDLINE    
Clozapine and some other atypical antipsychotics (e.g. quetiapine, olanzapine) have been found to exert a characteristic profile of action on operant behaviour maintained by progressive-ratio schedules, as revealed by Killeen's Mathematical Principles of Reinforcement model of schedule-controlled behaviour. These drugs increase the value of a parameter that expresses the 'incentive value' of the reinforcer (a) and a parameter that is inversely related to the organism's 'motor capacity' (δ). This experiment examined the effects of two further atypical antipsychotics, aripiprazole and amisulpride, on progressive-ratio schedule performance in rats; the effects of clozapine and a conventional antipsychotic, haloperidol, were also examined. In agreement with previous findings, clozapine (4, 8 mg kg⁻¹) increased a and δ, whereas haloperidol (0.05, 0.1 mg kg⁻¹) reduced a and increased δ. Aripiprazole (3,30 mg kg⁻¹) increased δ but did not affect a. Amisulpride (5, 50 mg kg⁻¹) had a delayed and protracted effect: δ was increased 3-6 hours after treatment; a was increased 1.5 hours, and reduced 12-24 hours after treatment. Interpretation based on Killeen's model suggests that aripiprazole does not share clozapine's ability to enhance reinforcer value. Amisulpride produced a short-lived enhancement, followed by a long-lasting reduction, of reinforcer value. Both drugs impaired motor performance.
F S den Boon; S Body; C L Hampson; C M Bradshaw; E Szabadi; N de Bruin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-10-03
Journal Detail:
Title:  Journal of psychopharmacology (Oxford, England)     Volume:  26     ISSN:  1461-7285     ISO Abbreviation:  J. Psychopharmacol. (Oxford)     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-02     Completed Date:  2013-01-11     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  8907828     Medline TA:  J Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1231-43     Citation Subset:  IM    
Psychopharmacology Section, Division of Psychiatry, University of Nottingham, Nottingham, UK.
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MeSH Terms
Antipsychotic Agents / administration & dosage,  adverse effects,  pharmacology*
Behavior, Animal / drug effects
Clozapine / administration & dosage,  adverse effects,  pharmacology
Conditioning, Operant / drug effects*
Dopamine Antagonists / administration & dosage,  adverse effects,  pharmacology*
Dose-Response Relationship, Drug
Haloperidol / administration & dosage,  adverse effects,  pharmacology
Models, Biological
Motor Activity / drug effects
Motor Skills / drug effects
Piperazines / administration & dosage,  adverse effects,  pharmacology*
Quinolones / administration & dosage,  adverse effects,  pharmacology*
Rats, Wistar
Reaction Time / drug effects
Reinforcement Schedule
Serotonin Antagonists / administration & dosage,  adverse effects,  pharmacology*
Sulpiride / administration & dosage,  adverse effects,  analogs & derivatives*,  pharmacology
Reg. No./Substance:
0/Antipsychotic Agents; 0/Dopamine Antagonists; 0/Piperazines; 0/Quinolones; 0/Serotonin Antagonists; 15676-16-1/Sulpiride; 52-86-8/Haloperidol; 5786-21-0/Clozapine; 82VFR53I78/aripiprazole; AA0G3TW31W/sultopride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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