Document Detail


Effects of amiodarone on wave front dynamics during ventricular fibrillation in isolated swine right ventricle.
MedLine Citation:
PMID:  11834505     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of acute amiodarone infusion on dynamics of ventricular fibrillation (VF) are unclear. Six isolated swine right ventricles (RVs) were studied in vitro. Activation patterns during VF were mapped optically, whereas action potentials were recorded with a glass microelectrode. At baseline, VF was associated with frequent spontaneous wave breaks. Amiodarone (2.5 microg/ml) reduced spontaneous wave breaks and increased the cycle length (CL) of VF from 83.3 +/- 17.8 ms at baseline to 118.4 +/- 25.8 ms during infusion (P < 0.05). Amiodarone increased the reentrant wave front CL (114.4 +/- 15.5 vs. 78.2 +/- 19.0 ms, P < 0.05) and central core area (4.1 +/- 3.8 vs. 0.9 +/- 0.3 mm2, P < 0.05). Within 30 min of infusion, VF terminated (n = 1), converted to ventricular tachycardia (VT) (n = 1) or continued at a slower rate (n = 4). Amiodarone flattened the APD restitution curves. We conclude that amiodarone reduced spontaneous wave breaks. It might terminate VF or convert VF to VT. These effects were associated with the flattening of APD restitution slope and increased core size of reentrant wave fronts.
Authors:
Chikaya Omichi; Shengmei Zhou; Moon-Hyoung Lee; Ajay Naik; Che-Ming Chang; Alan Garfinkel; James N Weiss; Shien-Fong Lin; Hrayr S Karagueuzian; Peng-Sheng Chen
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  282     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-02-08     Completed Date:  2002-04-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1063-70     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, University of California at Los Angeles School of Medicine, Los Angeles, California 90048-1865, USA.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects,  physiology
Amiodarone / pharmacology*
Animals
Anti-Arrhythmia Agents / pharmacology*
Diastole / drug effects
Membrane Potentials / drug effects,  physiology
Swine
Time Factors
Ventricular Fibrillation / physiopathology*
Ventricular Function, Right / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
HL-66389/HL/NHLBI NIH HHS; P50-HL-52319/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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