| Effects of aminobisphosphonate infusion on biochemical indices of bone metabolism in rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 2787185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a phase 1 study, seven patients with classical rheumatoid arthritis were treated with intravenous 3-amino-1-hydroxypropylidene-1-1-bisphosphonate (APD). Following this treatment, bone resorption as measured by fasting urine calcium/creatinine and hydroxyproline/creatinine ratios, was reduced. This was sustained for 6 months in only three patients. Elevations of these ratios often coincided with flares of active arthritis in the remaining four patients. Bone turnover as measured by serum osteocalcin levels was reduced in all patients but serum alkaline phosphatase levels remained unchanged. There was no consistent improvement in clinical indices of disease activity. |
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Authors:
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P L Tan; R Ames; S Yeoman; H K Ibbertson; D E Caughey |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of rheumatology Volume: 28 ISSN: 0263-7103 ISO Abbreviation: Br. J. Rheumatol. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-08-25 Completed Date: 1989-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302415 Medline TA: Br J Rheumatol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 325-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Immunobiology, University of Auckland School of Medicine, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arthritis, Rheumatoid / drug therapy, urine* Bone and Bones Calcium / urine Calcium-Binding Proteins / blood Creatinine / urine Diphosphonates / administration & dosage, therapeutic use* Drug Evaluation Female Humans Hydroxyproline / urine Infusions, Intravenous Male Middle Aged Osteocalcin |
| Chemical | |
Reg. No./Substance:
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0/Calcium-Binding Proteins; 0/Diphosphonates; 104982-03-8/Osteocalcin; 40391-99-9/pamidronate; 51-35-4/Hydroxyproline; 60-27-5/Creatinine; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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