| Effects of amino acid neurotransmitters on spontaneous muscular activity of the rumen amphistome, Gastrothylax crumenifer. | |
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MedLine Citation:
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PMID: 19476695 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Amino acid neurotransmitters play an important role in regulating neuromuscular activity of helminth parasites. The present study aimed to investigate the effects of different amino acid neurotransmitters [L-glutamate, glycine, gamma-aminobutyric acid (GABA)] on spontaneous muscular activity of isometrically mounted Gastrothylax crumenifer. L-Glutamate caused a significant increase in the amplitude and frequency of spontaneous contractions of rumen fluke at 10(-7)-10(-4) m and at 10(-5)-10(-4) m concentrations, respectively. Glycine application (10(-7)-10(-3) m) produced a significant decrease in the amplitude and frequency of spontaneous muscular contractions in a concentration-dependent manner, as compared to control amplitude (0.53 +/- 0.02 g) and frequency (51 +/- 4.65/5 min). Similarly, GABA produced a significant (P < 0.05) decrease in amplitude, baseline tension and frequency of spontaneous muscular contractions of G. crumenifer. To further substantiate the GABA effect, GABAA receptor antagonists, picrotoxin and bicuculline were applied. Picrotoxin (10(-5)-10(-3) m) caused a significant (P < 0.05) increase in amplitude, baseline tension and frequency of the rumen fluke as compared to control; whereas bicuculline did not elicit any observable effect in these attributes in isometrically mounted rumen flukes. These observations suggested that L-glutamate has an excitatory, whereas GABA and glycine have an inhibitory, effect on the spontaneous muscular activity of G. crumenifer. |
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Authors:
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P K Verma; D Kumar; S K Tandan |
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Publication Detail:
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Type: Journal Article Date: 2009-05-29 |
Journal Detail:
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Title: Journal of helminthology Volume: 83 ISSN: 1475-2697 ISO Abbreviation: J. Helminthol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-10-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985115R Medline TA: J Helminthol Country: England |
Other Details:
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Languages: eng Pagination: 385-9 Citation Subset: IM |
Affiliation:
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Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly 243 122, UP, India. drpawankv@yahoo.co.in |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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