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Effects of amino acid neurotransmitters on spontaneous muscular activity of the rumen amphistome, Gastrothylax crumenifer.
MedLine Citation:
PMID:  19476695     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Amino acid neurotransmitters play an important role in regulating neuromuscular activity of helminth parasites. The present study aimed to investigate the effects of different amino acid neurotransmitters [L-glutamate, glycine, gamma-aminobutyric acid (GABA)] on spontaneous muscular activity of isometrically mounted Gastrothylax crumenifer. L-Glutamate caused a significant increase in the amplitude and frequency of spontaneous contractions of rumen fluke at 10(-7)-10(-4) m and at 10(-5)-10(-4) m concentrations, respectively. Glycine application (10(-7)-10(-3) m) produced a significant decrease in the amplitude and frequency of spontaneous muscular contractions in a concentration-dependent manner, as compared to control amplitude (0.53 +/- 0.02 g) and frequency (51 +/- 4.65/5 min). Similarly, GABA produced a significant (P < 0.05) decrease in amplitude, baseline tension and frequency of spontaneous muscular contractions of G. crumenifer. To further substantiate the GABA effect, GABAA receptor antagonists, picrotoxin and bicuculline were applied. Picrotoxin (10(-5)-10(-3) m) caused a significant (P < 0.05) increase in amplitude, baseline tension and frequency of the rumen fluke as compared to control; whereas bicuculline did not elicit any observable effect in these attributes in isometrically mounted rumen flukes. These observations suggested that L-glutamate has an excitatory, whereas GABA and glycine have an inhibitory, effect on the spontaneous muscular activity of G. crumenifer.
Authors:
P K Verma; D Kumar; S K Tandan
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Publication Detail:
Type:  Journal Article     Date:  2009-05-29
Journal Detail:
Title:  Journal of helminthology     Volume:  83     ISSN:  1475-2697     ISO Abbreviation:  J. Helminthol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985115R     Medline TA:  J Helminthol     Country:  England    
Other Details:
Languages:  eng     Pagination:  385-9     Citation Subset:  IM    
Affiliation:
Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly 243 122, UP, India. drpawankv@yahoo.co.in
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