Document Detail

Effects of amino acid neurotransmitter candidates on an identified insect motoneurone.
MedLine Citation:
PMID:  2869456     Owner:  NLM     Status:  MEDLINE    
The cell body of the fast coxal depressor motoneurone (Df) was used to examine the effects of a group of putative amino acid neurotransmitters. gamma-Aminobutyric acid (GABA) elicited a biphasic hyperpolarizing response, each component having a separate reversal potential. Both components were affected by the GABA antagonist picrotoxinin. L-Glutamate produced a hyperpolarizing response with a reversal potential of between -80 and -85 mV, and L-aspartate gave a similar but less potent effect. Kainic acid and quisqualic acid elicited depolarizing responses of up to 10 mV in amplitude. beta-Alanine and taurine produced a single hyperpolarization with a reversal potential similar to glutamate. Glycine was ineffective on motoneurone Df.
K A Wafford; D B Sattelle
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  63     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-04-03     Completed Date:  1986-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  135-40     Citation Subset:  IM    
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MeSH Terms
Amino Acids / pharmacology*
Membrane Potentials / drug effects
Motor Neurons / drug effects*
Neurotransmitter Agents / pharmacology*
Reg. No./Substance:
0/Amino Acids; 0/Neurotransmitter Agents

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