Document Detail


Effects of amino acid deficiency on monoamines in the lateral hypothalamus (LH) in rats.
MedLine Citation:
PMID:  14609315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Animals decrease intake of an indispensable amino acid deficient diet, due in part to decreased dietary limiting amino acid concentrations within the anterior piriform cortex (APC). In addition to studies supporting a primary role for the APC in this phenomenon, recent studies have shown that the lateral hypothalamus (LH), which receives projections from the APC, also mediates the anorectic response to amino acid deficiency. The neurochemical changes within the LH that accompany the anorexia to amino acid deficiency are unclear. We hypothesized that norepinephrine (NE), dopamine (DA) and serotonin, whose levels are altered in response to amino acid deficiency within the APC, also act within the LH to mediate amino acid deficiency-induced anorexia. We determined that ingestion of an amino acid devoid diet increased concentrations of NE and the serotonin metabolite, 5-hydroxyindoleacetic acid in the LH. The 5-hydroxytryptamine metabolite was increased overall, according to analysis by area under the curve. Individual points reached significance at 130 min; NE was elevated at 170 min. These results suggest that the sustained anorectic response following ingestion of an amino acid devoid diet may be associated with increased activity of the NE and 5-hydroxytryptamine systems in the LH.
Authors:
J Ernie Blevins; Pok S Teh; Chen X Wang; Dorothy W Gietzen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  6     ISSN:  1028-415X     ISO Abbreviation:  Nutr Neurosci     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-11     Completed Date:  2003-12-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  291-9     Citation Subset:  IM    
Affiliation:
Division of Endocrinology/Metabolism, Department of Veterans Affairs Medical Center, University of Washington, Seattle, WA 91808, USA. jeblevin@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / deficiency*
Animals
Area Under Curve
Biogenic Monoamines / metabolism*
Diet
Electrochemistry / methods
Hydroxyindoleacetic Acid / metabolism
Hypothalamic Area, Lateral / metabolism*
Kinetics
Male
Norepinephrine / metabolism
Rats
Rats, Sprague-Dawley
Serotonin / metabolism
Grant Support
ID/Acronym/Agency:
DK07355/DK/NIDDK NIH HHS; DK35747/DK/NIDDK NIH HHS; NS043210/NS/NINDS NIH HHS; NS33347/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Biogenic Monoamines; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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