| Effects of ambient levels of air pollution generated by traffic on birth and placental weights in mice. | |
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MedLine Citation:
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PMID: 18222432 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To examine whether there is an association between fetal and/or placental weight and exposure to ambient levels of air pollution in mice. DESIGN: Chronic experiments on mice that were exposed to polluted vs. clean air. SETTING: Environmental exposure to atmospheric pollution. ANIMAL(S): Female Swiss mice (n = 70) were maintained at different stages of gestation in an exposure chamber located at an intersection with heavy traffic in a major city in Brazil. Control mice were maintained in a similar chamber, located adjacent to the exposure chamber but equipped with filters for particles and reactive gases. INTERVENTION(S): Animals were divided into six groups as follows: no exposure, exposure to a polluted chamber throughout gestation, exposure to a polluted chamber during the 1st week of pregnancy, exposure to a polluted chamber during the 2nd and 3rd weeks, exposure to a polluted chamber during the 1st and 2nd week, and exposure to a polluted chamber during the 3rd week. MAIN OUTCOME MEASURE(S): At the end of the gestational period, the determination of fetal and placental weight was performed after cesarean section. RESULT(S): Exposure to air pollution during the 1st week of pregnancy promoted a significant reduction in fetal weight. Mice exposed to polluted air, in any phase of gestation, presented with lower placental weight in comparison to mice maintained in clean chambers. CONCLUSION(S): Exposure to ambient levels of traffic pollution at early phases of gestation is a determinant for decreased final fetal weight. Placental weight is reduced with exposure to air pollution at any phase of gestation. |
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Authors:
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Ingrid Ramos Rocha E Silva; Ana Julia F C Lichtenfels; Luis Alberto Amador Pereira; Paulo H N Saldiva |
Publication Detail:
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Type: Journal Article Date: 2008-01-28 |
Journal Detail:
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Title: Fertility and sterility Volume: 90 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-10 Completed Date: 2008-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1921-4 Citation Subset: IM |
Affiliation:
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Department of Pathology, Laboratory of Air Pollution, University of São Paulo, São Paulo, Brazil. rors@terra.com.br |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Air Pollutants
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toxicity* Animals Animals, Newborn Atmosphere Exposure Chambers Birth Weight / drug effects* Cesarean Section Female Fetal Weight / drug effects* Gestational Age Maternal Exposure Mice Organ Size Placenta / drug effects*, growth & development Vehicle Emissions / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants; 0/Vehicle Emissions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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